Apolipoprotein O,载脂蛋白O抗体

产品编号HZ-12502R
英文名称Apolipoprotein O
中文名称载脂蛋白O抗体
别 名ApoO; 0610008C08Rik; 1110019O03Rik; Apolipoprotein O; APOO; APOO_HUMAN; FAM121B; Family with sequence similarity 121B; MGC130105; MGC130106; MGC4825; My025; MYO25; OTTHUMP00000023073; Protein FAM121B; RP23-272D10.2.
说 明 书0.1ml 0.2ml
研究领域肿瘤 心血管 细胞生物 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
Apolipoprotein O,载脂蛋白O抗体交叉反应Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep,
产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞膜 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ApoO/Apolipoprotein O
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Apolipoprotein O,载脂蛋白O抗体PubMedPubMed
产品介绍background:
Apolipoproteins are a family of fatty-acid binding proteins that transport fat through the bloodstream in the form of lipoproteins. ApoO (Apolipoprotein O), also known as FAM121B or My025, is a 198 amino acid single-pass membrane protein that belongs to the apolipoprotein family. Expressed ubiquitously with particularly high expression in diabetic heart tissue, apoO functions to promote the transport of cholesterol from macrophage cells and may be involved in regulatory mechanisms that protect lipid accumulation within the heart. ApoO is present in high density lipoproteins (HDLs) and low density lipoproteins (LDLs) and is secreted by an MTP (microsomal triglyceride transfer protein)-dependent mechanism. Two isoforms of apoO exist due to alternative splicing events.

Function:
Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. May be involved in myocardium-protective mechanisms against lipid accumulation.

Subcellular Location:
Membrane. Secreted.

Tissue Specificity:
Expressed in all tissues examined. Up-regulated in diabetic heart.

Apolipoprotein O,载脂蛋白O抗体Post-translational modifications:
O-glycosylation; glycosaminoglycan of chondroitin-sulfate type.

Similarity:
Belongs to the apolipoprotein O family.

Database links:
Entrez Gene: 79135 Human
Entrez Gene: 68316 Mouse
Omim: 300753 Human
SwissProt: Q9BUR5 Human
SwissProt: Q9DCZ4 Mouse
Unigene: 495851 Human
Unigene: 343319 Mouse
Unigene: 379156 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.