ARPC4,肌动蛋白相关蛋白2/3亚型4抗体

产品编号HZ-12528R
英文名称ARPC4
中文名称肌动蛋白相关蛋白2/3亚型4抗体
别 名Actin related protein 2/3 complex subunit 4; Actin related protein 2/3 complex subunit 4 20 kD; Actin related protein 2/3 complex subunit 4 20kDa; Actin-related protein 2/3 complex subunit 4; ARC20; Arp2/3 complex 20 kDa subunit; Arp2/3 protein complex subunit p20; ARPC 4; ARPC4; ARPC4_HUMAN; MGC13544; OTTHUMP00000165252; OTTHUMP00000207520; p20 Arc; p20-ARC; p20ARC.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 结合蛋白 细胞骨架
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Chicken, Cow, Rabbit, Zebrafish, Sheep, Xenopus laevis
ARPC4,肌动蛋白相关蛋白2/3亚型4抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量20kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ARPC4/p20-ARC
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ARPC4,肌动蛋白相关蛋白2/3亚型4抗体PubMedPubMed
产品介绍background:
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation and high-affinity binding to F-actin. Alternative splicing results in multiple transcript variants. Naturally occurring read-through transcription exists between this gene and the downstream tubulin tyrosine ligase-like family, member 3 (TTLL3), which results in the production of a fusion protein. [provided by RefSeq, Nov 2010].

Function:
Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.

Subunit:
Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC.

Subcellular Location:
Cytoplasm; cytoskeleton. Cell projection.

Similarity:
Belongs to the ARPC4 family.

ARPC4,肌动蛋白相关蛋白2/3亚型4抗体Database links:
Entrez Gene: 10093 Human
Entrez Gene: 68089 Mouse
Entrez Gene: 539459 Cow
Entrez Gene: 100155875 Pig
Entrez Gene: 297518 Rat
Entrez Gene: 114456 Zebrafish
Omim: 604226 Human
SwissProt: Q148J6 Cow
SwissProt: P59998 Human
SwissProt: P59999 Mouse
Unigene: 323342 Human
Unigene: 289306 Mouse
Unigene: 472172 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.