BAG2,Bcl-2结合抑凋亡蛋白2抗体

产品编号HZ-5134R
英文名称BAG2
中文名称Bcl-2结合抑凋亡蛋白2抗体
别 名BAG 2; BAG-2; BAG family molecular chaperone regulator 2; BAG-2; Bag2; BAG2_HUMAN; BCL 2 associated athanogene 2; Bcl-2-associated athanogene 2; BCL2 associated athanogene 2; dJ417I1.2; KIAA0576; MGC149462.
说 明 书0.1ml 0.2ml
研究领域肿瘤 免疫学 信号转导 细胞凋亡 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Cow, Horse,
BAG2,Bcl-2结合抑凋亡蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量24kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human BAG2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
BAG2,Bcl-2结合抑凋亡蛋白2抗体PubMedPubMed
产品介绍background:
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq].

Function:
Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.

Similarity:
Contains 1 BAG domain.

Database links:
Entrez Gene: 9532 Human
Omim: 603882 Human
SwissProt: O95816 Human
Unigene: 55220 Human

BAG2,Bcl-2结合抑凋亡蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.