phospho-Acetyl Coenzyme A Carboxylase alpha,***酸化乙酰辅酶A羧化酶抗体

产品编号HZ-12954R
英文名称phospho-Acetyl Coenzyme A Carboxylase alpha (Ser80)
中文名称***酸化乙酰辅酶A羧化酶抗体
别 名Acetyl Coenzyme A Carboxylase alpha (phospho S80); p-Acetyl Coenzyme A Carboxylase alpha (phospho S80); ACAC; ACACA; ACACA; ACACA_HUMAN; ACC alpha; ACC; ACC-alpha; ACC1; ACC1; ACCA; acetyl CoA carboxylase 1; acetyl Coenzyme A; Acetyl Coenzyme A; Biotin carboxylase; Acetyl-Coenzyme A Carboxylase alpha.
说 明 书0.1ml
产品类型***酸化抗体
研究领域肿瘤 心血管 细胞生物 转录调节因子
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat,
phospho-Acetyl Coenzyme A Carboxylase alpha,***酸化乙酰辅酶A羧化酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量265kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthesised phosphopeptide derived from human Acetyl Coenzyme A Carboxylase alpha around the phosphorylation site of Ser80
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
phospho-Acetyl Coenzyme A Carboxylase alpha,***酸化乙酰辅酶A羧化酶抗体PubMedPubMed
产品介绍background:
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Subunit:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in brain, placental, skeletal muscle, renal, pancreatic and adipose tissues; expressed at low level in pulmonary tissue; not detected in the liver.

Post-translational modifications:
Phosphorylation on Ser-1263 is required for interaction with BRCA1.

phospho-Acetyl Coenzyme A Carboxylase alpha,***酸化乙酰辅酶A羧化酶抗体DISEASE:
Defects in ACACA are a cause of acetyl-CoA carboxylase 1 deficiency (ACACAD) [MIM:613933]; also known as ACAC deficiency or ACC deficiency. An inborn error of de novo fatty acid synthesis associated with severe brain damage, persistent myopathy and poor growth.

Similarity:
Contains 1 ATP-grasp domain.
Contains 1 biotin carboxylation domain.
Contains 1 biotinyl-binding domain.
Contains 1 carboxyltransferase domain. Contains 1 carboxyltransferase domain.

Gene ID:
31

Database links:
Entrez Gene: 31 Human
Entrez Gene: 32 Human
Entrez Gene: 107476 Mouse
Entrez Gene: 60581 Rat
Omim: 200350 Human
SwissProt: O00763 Human
SwissProt: Q13085 Human
SwissProt: Q5SWU9 Mouse
SwissProt: P11497 Rat
Unigene: 160556 Human
Unigene: 234898 Human
Unigene: 31374 Mouse
Unigene: 163753 Rat
Unigene: 217177 Rat
Unigene: 44372 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.