CST9,胱抑素9/半胱氨酸蛋白酶抑制剂9抗体

产品编号HZ-9217R
英文名称CST9
中文名称胱抑素9/半胱氨酸蛋白酶抑制剂9抗体
别 名M12; CLM; Cresp; Cst9; CST9_HUMAN; Cystatin 9 (testatin); Cystatin like molecule; Cystatin-9; Cystatin-like molecule; Testatin.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
CST9,胱抑素9/半胱氨酸蛋白酶抑制剂9抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
细胞定位细胞浆 分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CST9/Cystatin 9
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CST9,胱抑素9/半胱氨酸蛋白酶抑制剂9抗体PubMedPubMed
产品介绍background:
The cystatin superfamily is a well-established family of cysteine protease inhibitors. All true cystatins inhibit cysteine peptidases of the papain family, such as cathepsins, while some also inhibit legumain family enzymes. The CRES (cystatin-related epididymal spermatogenic) protein defines a new subgroup in the family 2 cystatins of the cystatin superfamily. CRES proteins lack two of the three consensus sites necessary for the cystatin inhibition of C1 cysteine proteases. Due to their expression patterns, it is likely that CRES proteins may perform unique and tissue-specific functions in the reproductive and neuroendocrine systems. As a member of the CRES subfamily, Cystatin 9, also designated CLM, is a 159 amino acid protein that is expressed in heart, placenta, lung, liver, skeletal muscle and pancreas. Cystatin 9 is thought to play a role in hematopoietic differentiation or inflammation. It has also been shown to be upregulated by LPS in some cancer cell lines, such as promyelocytic leukemia (HL-60) and myelomonocytic leukemia.

Function:
May play a role in hematopoietic differentiation or inflammation.

Subcellular Location:
Secreted. May be targeted through the Golgi via the secretory pathway.

Tissue Specificity:
Expressed in heart, placenta, lung, liver, skeletal muscle and pancreas. Not expressed in brain. Barely expressed in tumor cell lines except for breast adenocarcinoma MCF-7 cells and U251 cells.

Similarity:
Belongs to the cystatin family.

Gene ID:
128822

CST9,胱抑素9/半胱氨酸蛋白酶抑制剂9抗体Database links:
Entrez Gene: 128822 Human
SwissProt: Q5W186 Human
Unigene: 698020 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.