Syntrophin gamma 2,肌蛋白结合蛋白γ2抗体

产品编号HZ-11065R
英文名称Syntrophin gamma 2
中文名称肌蛋白结合蛋白γ2抗体
别 名G2SYN; Gamma2-syntrophin; SNTG2; SYN5; Syntrophin-5; Syntrophin5; Syntrophin 5; Syntrophin gamma 2; SNTG2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 通道蛋白 细胞粘附分子 细胞外基质
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
Syntrophin gamma 2,肌蛋白结合蛋白γ2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human SNTG2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Syntrophin gamma 2,肌蛋白结合蛋白γ2抗体PubMedPubMed
产品介绍background:
Syntrophins are cytoplasmic peripheral membrane proteins that bind to components of mechanosenstive sodium channels and the extreme carboxy-terminal domain of dystrophin and dystrophin-related proteins. The PDZ domain of this protein product interacts with a protein component of a mechanosensitive sodium channel that affects channel gating. Absence or reduction of this protein product has been associated with Duchenne muscular dystrophy.

Function:
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex (By similarity).

Subunit:
Interacts with the dystrophin protein DMD and related proteins DTNA and DTNB.

Subcellular Location:
Cell membrane, sarcolemma; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Note=In skeletal muscle, it localizes at the cytoplasmic side of the sarcolemmal membrane.

Tissue Specificity:
Widely expressed. Strong expression in brain and testis. In CNS, it is expressed in the perikaryon and proximal portion of the neuronal processes. Strong expression in the hippocampus, neuron-rich dendate granule cells, and pyramidal cell layers. Highly expressed in neurons of the cerebral cortex. Also expressed in the cerebellar cortex, deep cerebellar nuclei, thalamus, and basal ganglia.

Similarity:
Belongs to the syntrophin family.
Contains 1 PDZ (DHR) domain.
Contains 1 PH domain.

Syntrophin gamma 2,肌蛋白结合蛋白γ2抗体Database links:
Entrez Gene: 54221 Human
Omim: 608715 Human
SwissProt: Q9NY99 Human
Unigene: 449545 Human
Unigene: 526395 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.