CT135/ODF3,肿瘤/睾丸抗原135抗体

产品编号HZ-9406R
英文名称CT135/ODF3
中文名称肿瘤/睾丸抗原135抗体
别 名Cancer/testis antigen 135; CT135; hSHIPPO; odf3; ODF3A_HUMAN; Outer dense fiber of sperm tails 3; Outer dense fiber of sperm tails protein 3; Outer dense fiber protein 3; SHIPPO1; Sperm tail protein SHIPPO 1; Sperm tail protein SHIPPO1; TISP50; Transcript induced in spermiogenesis protein 50.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 发育生物学 细胞周期蛋白 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep,
CT135/ODF3,肿瘤/睾丸抗原135抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ODF3/CT135
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CT135/ODF3,肿瘤/睾丸抗原135抗体PubMedPubMed
产品介绍background:
Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.
Constituting the main cytoskeletal structure of spermatid flagella, outer dense fibers (ODFs) add elastic recoil, stiffness and protection against shear forces during sperm movement. Human ODFs consist of approximately 10 major and at least 15 minor proteins. The major proteins of the ODF include Odf1, Odf2, and Odf3, which compose a family of proteins that are preferentially expressed during mammalian spermiogenesis. Odf3 (outer dense fiber protein 3), also known as sperm tail protein SHIPPO 1 and TISP50 (transcript induced in spermiogenesis protein 50), is a 254 amino acid protein that is expressed during the latter part of spermatogenesis in flagella of elongated spermatids and mature sperm. Odf proteins are directed to their exact subcellular location by Spags, which are characterized as chaperone-like Odf-binding molecules. There are two isoforms of Odf3 that are produced as a result of alternative splicing events.

Function:
Outer dense fibers are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail. May help to maintain the passive elastic structures and elastic recoil of the sperm tail.

Subcellular Location:
Cytoplasm. Expressed in the cytoplasmic lobe of spermatids.

Tissue Specificity:
Testis-specific.

CT135/ODF3,肿瘤/睾丸抗原135抗体Similarity:
Belongs to the ODF3 family.
Contains 2 STPGR (Sperm-tail PG-rich) repeats.

Gene ID:
113746

Database links:
Entrez Gene: 113746 Human
Entrez Gene: 69287 Mouse
Omim: 608356 Human
SwissProt: Q96PU9 Human
SwissProt: Q920N1 Mouse
Unigene: 350949 Human

CT135/ODF3,肿瘤/睾丸抗原135抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.