MURF2,肌肉特异性环指蛋白2抗体

产品编号HZ-9389R
英文名称MURF2
中文名称肌肉特异性环指蛋白2抗体
别 名MURF 2; MURF-2; MuRF2; Muscle specific ring finger 2; Muscle specific RING finger protein 2; Muscle-specific RING finger protein 2; ring finger protein 29; RNF 29; RNF29; TRI55_HUMAN; TRIM 55; Trim55; Tripartite motif containing 55; Tripartite motif containing protein 55; Tripartite motif-containing protein 55.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 细胞周期蛋白 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit,
MURF2,肌肉特异性环指蛋白2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量60kDa
细胞定位细胞核 细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human MURF2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
MURF2,肌肉特异性环指蛋白2抗体PubMedPubMed
产品介绍background:
MuRF1 (RNF28), MuRF2 (RNF29) and MuRF3 (RNF30) are a specific class of RING finger proteins expressed in striated muscle tissues that act as signaling molecules and cytoskeletal adaptors. The MuRF proteins contain a conserved N-terminal RING domain and zinc-binding B-box motif in addition to two coiled-coil motifs in their central regions. In muscle cells, MuRF2 regulates gene expression and protein turnover. It localizes to the cytoplasm, but under atrophic conditions it is detected in the nucleus. MuRF2 can form oligomers with various other proteins, including titin and myosin, during sarcomere assembly. Endogenous MuRF2 associates with the sarcomeric M-band in cardiomyocytes. There are at least four isoforms of MuRF2.

Subunit:
Homooligomer and heterooligomer (Probable). Interacts with titin/TTN. Interacts with myosins. Interacts with SQSTM1 and NBR1. Isoform 4 may not able to interact with isoform 1, isoform 2 and isoform 3. Probably interacts with TRIM63 and TRIM54.

Subcellular Location:
Cytoplasm. Nucleus. Note=Nuclear under atrophic conditions and upon mechanical signals. Localizes to the sarcomeric M-band in cardiomyocytes. Colocalizes in part with microtubules.

Tissue Specificity:
Highly expressed in muscle. Low-level expression in liver.

MURF2,肌肉特异性环指蛋白2抗体Similarity:
Contains 1 B box-type zinc finger.
Contains 1 COS domain.
Contains 1 RING-type zinc finger.

Gene ID:
84675

Database links:
Entrez Gene: 84675 Human
Entrez Gene: 381485 Mouse
Entrez Gene: 365751 Rat
Omim: 606469 Human
SwissProt: Q9BYV6 Human
SwissProt: Q5PQN5 Rat
Unigene: 85524 Human
Unigene: 35419 Mouse
Unigene: 76142 Rat

MURF2,肌肉特异性环指蛋白2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.