FGF14,成纤维细胞生长因子14抗体

产品编号HZ-9761R
英文名称FGF14
中文名称成纤维细胞生长因子14抗体
别 名FHF 4; FHF-4; FHF4; Fibroblast growth factor 14; Fibroblast growth factor homologous factor 4; mFHF-4(1B); FGF14_HUMAN.
说 明 书0.1ml 0.2ml
研究领域神经生物学 信号转导 生长因子和*** 激酶和***酸酶
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Cow, Horse, Sheep,
FGF14,成纤维细胞生长因子14抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量28kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FGF14
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FGF14,成纤维细胞生长因子14抗体PubMedPubMed
产品介绍background:
Fibroblast growth factor-1 (FGF-1), also designated acidic FGF, and fibroblast growth factor-2 (FGF-2), also designated basic FGF, are members of a family of growth factors that stimulate proliferation of cells of mesenchymal, epithe-lial and neuroectodermal origin. Additional members of the FGF family include the oncogenes FGF-3 (Int2) and FGF-4 (hst/Kaposi), FGF-5, FGF-6, FGF-7 (KGF), FGF-8 (AIGF), FGF-9 (GAF) and FGF-10–FGF-23. Members of the FGF family share 30-55% amino acid sequence identity and similar gene structure, and are capable of transforming cultured cells when overexpressed in transfected cells. Cellular receptors for FGFs are members of a second multigene family including four tyrosine kinases, designated Flg (FGFR-1), Bek (FGFR-L), TKF and FGFR-3.

Function:
Probably involved in nervous system development and function.

Subcellular Location:
Nuclear

Tissue Specificity:
Nervous system.

FGF14,成纤维细胞生长因子14抗体DISEASE:
Defects in FGF14 are the cause of spinocerebellar ataxia type 27 (SCA27) [MIM:609307]. Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA27 is an autosomal dominant cerebellar ataxia (ADCA). It is a slowly progressive disorder, with onset in late-childhood to early adulthood, characterized by ataxia with tremor, orofacial dyskinesia, psychiatric symptoms and cognitive deficits.

Similarity:
Belongs to the heparin-binding growth factors family.

Database links:
Entrez Gene: 2259 Human
Entrez Gene: 14169 Mouse
Entrez Gene: 63851 Rat
Omim: 601515 Human
SwissProt: Q92915 Human
SwissProt: P70379 Mouse
SwissProt: Q8R5L7 Rat
Unigene: 508616 Human
Unigene: 44476 Rat

FGF14,成纤维细胞生长因子14抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.