FASP1,MaFF相关蛋白抗体

产品编号HZ-9738R
英文名称FASP1
中文名称MaFF相关蛋白抗体
别 名B28; C21orf46; FASP1; hMis18alpha; MaFF interacting protein; MAFIP; MIS18A; Protein Mis18 alpha; MS18A_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 细胞周期蛋白 细胞分化
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Dog, Horse, Sheep,
FASP1,MaFF相关蛋白抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量26kDa
细胞定位细胞核
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human FASP1/C21orf45
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
FASP1,MaFF相关蛋白抗体PubMedPubMed
产品介绍background:
Mapping to chromosome 21, the FASP1 gene (FAPP1-associated protein 1) encodes a 233 amino acid protein that is homologous to the fission yeast protein Mis18. In yeast, Mis18 is localized to the centrosome and forms a complex with Mis16 to maintain the deacetylated state of histones specifically in the central core of centromeres. FASP1, also known as Protein Mis18-alpha and C21orf45, is required for the recruitment of CENP-A to centrosomes and is thereby essential for normal chromosome segregation during mitosis. With expression in testis, FASP1 exists as a homodimer, a heterodimer with MIS18B or is present in a complex containing other Mis18 family members. FASP1 has been shown to bind to pp5644 in Hela cells, where overexpression of pp5644 leads to inhibited growth and colony formation.

Function:
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.

Subunit:
Homodimer, and heterodimer with MIS18B. Identified in a complex containing MIS18A, MIS18B, MIS18BP1, RBBP7 and RBBP4.

Subcellular Location:
Nucleus. Centromere.

Tissue Specificity:
Detected in testis.

Similarity:
Belongs to the mis18 family.

Database links:
Entrez Gene: 54069 Human
SwissProt: Q9NYP9 Human

FASP1,MaFF相关蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.