PTP zeta,***酸蛋白聚糖PTPRZ抗体

产品编号HZ-11327R
英文名称PTP zeta
中文名称***酸蛋白聚糖PTPRZ抗体
别 名Phosphacan; 3F8 chondroitin sulfate proteoglycan; 3H1 keratan sulfate proteoglycan; HPTPZ; HPTPzeta; Phosphacan; Protein tyrosine phosphatase receptor type Z polypeptide 2; Protein tyrosine phosphatase, receptor type, Z polypeptide 1; Protein tyrosine phosphatase, receptor type, zeta polypeptide 1; PTP-ZETA; PTP18; PTPRZ; PTPRZ1; PTPZ; R PTP zeta 2; R-PTP-zeta; Receptor type tyrosine phosphatase beta/zeta; Receptor-type tyrosine-protein phosphatase zeta; RPTP-BETA; RPTPB; RPTPbeta; PTPRZ_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 神经生物学 信号转导 激酶和***酸酶 细胞类型标志物
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
PTP zeta,***酸蛋白聚糖PTPRZ抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量251kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Phosphacan
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PTP zeta,***酸蛋白聚糖PTPRZ抗体PubMedPubMed
产品介绍background:
PTP zeta (receptor-type protein tyrosine phosphatase zeta) is a type I membrane protein chondroitin sulfate proteoglycan with a transmembrane domain and intracellular tyrosine phosphatase domains. PTP zeta may be involved in the regulation of specific developmental processes in the CNS. PTP zeta is developmentally regulated in the brain and specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. PTP zeta belongs to the protein-tyrosine phosphatase family and contains 1 eukaryotic-type carbonic anhydrase domain, 1 fibronectin type III domain and 2 tyrosine-protein phosphatase domains.

Function:
May be involved in the regulation of specific developmental processes in the CNS.

Subunit:
The carbonic-anhydrase like domain binds to contactin (By similarity).

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Tissue Specificity:
Specifically expressed in the central nervous system, where it is localized in the Purkinje cell layer of the cerebellum, the dentate gyrus, and the subependymal layer of the anterior horn of the lateral ventricle. Developmentally regulated in the brain.

Similarity:
Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.
Contains 1 alpha-carbonic anhydrase domain.
Contains 1 fibronectin type-III domain.
Contains 2 tyrosine-protein phosphatase domains.

Database links:
Entrez Gene: 5803 Human
Entrez Gene: 19283 Mouse
Entrez Gene: 25613 Rat
Omim: 176891 Human
SwissProt: P23471 Human
SwissProt: Q62656 Rat
Unigene: 489824 Human
Unigene: 10088 Rat

PTP zeta,***酸蛋白聚糖PTPRZ抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.