DZIP3,RNA结合泛素连接酶DZIP3抗体

产品编号HZ-12191R
英文名称DZIP3
中文名称RNA结合泛素连接酶DZIP3抗体
别 名DAZ-interacting protein 3; DAZ interacting protein 3, zinc finger; E3 ubiquitin-protein ligase DZIP3; hRUL138; KIAA0675; UURF2; RNA-binding ubiquitin ligase of 138 kDa; DZIP3_HUMAN.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 锌指蛋白 表观遗传学 泛素
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Cow, Horse, Rabbit,
DZIP3,RNA结合泛素连接酶DZIP3抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量139kDa
细胞定位细胞浆
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from Human DZIP3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DZIP3,RNA结合泛素连接酶DZIP3抗体PubMedPubMed
产品介绍background:
DZIP3 is a 1,208 amino acid protein that localizes to the cytoplasm and contains one RING-type zinc finger. Expressed in a variety of tissues with highest expression in heart, skeletal muscle and kidney, DZIP3 functions as an E3 ubiquitin-protein ligase that accepts ubiquitin from an E2 ubiquitin-conjugating enzyme, thereby playing a role in signaling events throughout the cell. Multiple isoforms of DZIP3 exist due to alternative splicing events.

Function:
E3 Ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Able to specifically bind RNA.

Subunit:
Interacts with DAZ proteins.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Widely expressed at low level. Highly expressed in skeletal muscle, kidney and heart. Expressed at low level in placenta, lung, brain, liver and pancreas.

Similarity:
Contains 1 RING-type zinc finger.

Database links:
UniProtKB/Swiss-Prot: Q86Y13.2

DZIP3,RNA结合泛素连接酶DZIP3抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.