Macrophage mannose receptor 1,巨噬细胞甘露糖受体CD206抗体

产品编号HZ-2664R
英文名称Macrophage mannose receptor 1
中文名称巨噬细胞甘露糖受体CD206抗体
别 名Mannose Receptor; Macrophage mannose receptor 1; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor 1; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; OTTHUMP00000045206; MRC1_HUMAN; MRC1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.
说 明 书0.1ml 0.2ml
研究领域肿瘤 细胞生物 免疫学 转录调节因子 细胞膜受体 糖蛋白
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, Sheep,
Macrophage mannose receptor 1,巨噬细胞甘露糖受体CD206抗体产品应用IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量160kDa
细胞定位细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CLEC13D
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Macrophage mannose receptor 1,巨噬细胞甘露糖受体CD206抗体PubMedPubMed
产品介绍background:
The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment. This gene is in close proximity to MRC1L1. The gene loci including this gene, MRC1L1, as well as LOC340843 and LOC340893, consist of two nearly identical, tandemly linked genomic regions, which are thought to be a part of a duplicated region. [provided by RefSeq].

Function:
Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains. Acts as phagocytic receptor for bacteria, fungi and other pathogens.

Subcellular Location:
Endosome membrane; Single-pass type I membrane protein. Cell membrane; Single-pass type I membrane protein.

Similarity:
Contains 8 C-type lectin domains.
Contains 1 fibronectin type-II domain.
[SIMILARITY] Contains 1 ricin B-type lectin domain.

Gene ID:
4360

Macrophage mannose receptor 1,巨噬细胞甘露糖受体CD206抗体Database links:
Entrez Gene: 4360 Human
Entrez Gene: 17533 Mouse
Entrez Gene: 291327 Rat
Omim: 153618 Human
SwissProt: P22897 Human
SwissProt: Q61830 Mouse
Unigene: 75182 Human
Unigene: 2019 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

巨噬细胞甘露糖受体,主要存在于巨噬细胞膜表面的模式识别受体，能够特异性识别甘露糖、岩藻糖或N-乙酰葡糖胺，介导巨噬细胞吞噬抗原，启动免疫反应.

产品图片

Tissue/cell: rat transplant lymphoma tissue; 4% Paraformaldehyde-fixed and paraffin-embedded;  Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min;  Incubation: Anti-MRC1/CD206 Polyclonal Antibody, Unconjugated(HZ-2664R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining