CYP8A1,前列环素合成酶抗体

产品编号HZ-3677R
英文名称CYP8A1
中文名称前列环素合成酶抗体
别 名CYP8; CYP8A1; Cytochrome P450, family 8, subfamily A, polypeptide 1; PGIS; Prostacyclin synthase; Prostaglandin I2 (prostacyclin) synthase; Prostaglandin I2 synthase; PTGI.
说 明 书0.1ml 0.2ml
研究领域心血管 细胞生物 免疫学 糖尿病 新陈代谢
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse,
CYP8A1,前列环素合成酶抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CYP8A1/PTGIS
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CYP8A1,前列环素合成酶抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis.

Subcellular Location:
Endoplasmic reticulum membrane; Single-pass membrane protein.

Tissue Specificity:
Widely expressed; particularly abundant in ovary, heart, skeletal muscle, lung and prostate.

Similarity:
Belongs to the cytochrome P450 family.

CYP8A1,前列环素合成酶抗体Database links:
Entrez Gene: 5740 Human
Entrez Gene: 19223 Mouse
Entrez Gene: 25527 Rat
Omim: 601699 Human
SwissProt: Q29626 Cow
SwissProt: Q16647 Human
SwissProt: O35074 Mouse
SwissProt: Q62969 Rat
Unigene: 5247 Cow
Unigene: 302085 Human
Unigene: 2339 Mouse
Unigene: 73051 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.