CES3,羧酸酯酶3抗体

产品编号HZ-13869R
英文名称CES3
中文名称羧酸酯酶3抗体
别 名Carboxylesterase 3; CES 3; Ces3; ES3; EST3_HUMAN; FLJ21736; Liver carboxylesterase 31 homolog.
说 明 书0.1ml 0.2ml
研究领域细胞生物 信号转导 新陈代谢 表观遗传学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
CES3,羧酸酯酶3抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量62kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human CES3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
CES3,羧酸酯酶3抗体PubMedPubMed
产品介绍background:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as *** and ***, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Subcellular Location:
Endoplasmic reticulum lumen.

Tissue Specificity:
Expressed in liver, colon and small intestine.

Post-translational modifications:
N-glycosylated.

Similarity:
Belongs to the type-B carboxylesterase/lipase family.

Gene ID:
23491

CES3,羧酸酯酶3抗体Database links:
Entrez Gene: 23491 Human
Omim: 605279 Human
SwissProt: Q6UWW8 Human
Unigene: 268700 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.