C1orf220,1号染色体开放阅读框220抗体
英文名称： Anti-C1orf220 antibody
型号:null    抗体货号： HZ-15059R
价格:请致电：010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

C1orf220,1号染色体开放阅读框220抗体

产品编号HZ-15059R
英文名称C1orf220
中文名称1号染色体开放阅读框220抗体
别 名Chromosome 1 open reading frame 22; Putative uncharacterized protein C1orf220; CA220_HUMAN.
说 明 书0.1ml 0.2ml
研究领域细胞生物 免疫学
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human,
C1orf220,1号染色体开放阅读框220抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human C1orf220
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
C1orf220,1号染色体开放阅读框220抗体PubMedPubMed
产品介绍Gene ID:
400798

Database links:
Entrez Gene: 400798 Human
SwissProt: Q5T0J3 Human
Unigene: 668085 Human


C1orf220,1号染色体开放阅读框220抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

S gene are the cause of cystinosis.

Subcellular Location:
Lysosome membrane; Multi-pass membrane protein.

Tissue Specificity:
Strongly expressed in pancreas, kidney (adult and fetal) and in skeletal muscle. Expressed at lower levels in placenta and heart. Weakly expressed in lung, liver and brain (adult and fetal).

CTNS,胱氨酸抗体DISEASE:
Defects in CTNS are the cause of cystinosis nephropathic type (CTNS) [MIM:219800]. It is a form of cystinosis, a lysosomal storage disease due to defective transport of cystine across the lysosomal membrane. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. The classical nephropathic form has onset in the first year of life and is characterized by a polyuro-polydipsic syndrome, marked height-weight growth delay, generalized impaired proximal tubular reabsorptive capacity, with severe fluid-electrolyte balance alterations, renal failure, ocular symptoms and other systemic complications.
Defects in CTNS are the cause of cystinosis adult non-nephropathic type (CTNSANN) [MIM:219750]. It is a form of cystinosis, a lysosomal storage disease due to defective transport of cystine across the lysosomal membrane. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. Cystinosis adult non-nephropathic type is characterized by ocular features and a benigne course. Patients manifest mild photophobia due to conjunctival and corneal cystine crystals.
Defects in CTNS are the cause of cystinosis late-onset juvenile or adolescent nephropathic type (CTNSJAN) [MIM:219900]. It is a form of cystinosis, a lysosomal storage disease due to defective transport of cystine across the lysosomal membrane. This results in cystine accumulation and crystallization in the cells causing widespread tissue damage. Late-onset juvenile or adolescent nephropathic cystinosis manifests itself first at age 10 to 12 years with proteinuria due to glomerular damage rather than with the manifestations of tubular damage that occur first in infantile cystinosis. There is no excess amino aciduria and stature is normal. Photophobia, late development of pigmentary retinopathy, and chronic headaches are features.

Similarity:
Belongs to the cystinosin family.
Contains 2 PQ-loop domains.

Database links:
UniProtKB/Swiss-Prot: O60931.2

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

SP-0023) and DAB(C-0010) staining

Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-C1S Polyclonal Antibody, Unconjugated(HZ-15088R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

r>
Storage / Stability
 -20°C/1 year
Human Gene ID
 84210
Human Swiss-Prot No.
 Q5TYW2
Reactivity
 Human
Applications
 WB ELISA
Dilution
 Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Predicted band (Da)
 94048
Observed band (KDa)
 95
  A20 Polyclonal Antibody Images
Western blot analysis of 3T3 using A20 antibody.. Secondary antibody（catalog#：RS0002) was diluted at 1:20000