G-protein coupled receptor (GPCR) kinase interacting proteins 1 and 2 (GIT-1 and GIT-2) are highly conserved,ubiquitous scaffold proteins involved in localizedsignaling to help regulate focal contact assembly andcytoskeletal dynamics. GIT proteins contain multipleinteraction domains that allow interaction with smallGTPases (including ARF, Rac and cdc42), kinases (such asPAK and MEK), the Rho family GEF PIX, and the focaladhesion protein paxillin (reviewed in 1). GIT-1 islocalized to focal adhesions, cytoplasmic complexes andmembrane protrusions, and regulates cell protrusionformation and cell migration (2). GIT-1 has also beenimplicated in neuronal functions including synapseformation (3) and the pathology of Huntington disease(4). Huntington disease is a genetic neurodegenerativecondition involving a mutation in the huntington gene.The huntington gene product (htt) is ubiquitinated anddegraded in human Huntington disease brains (5). Httinteracts directly with GIT-1 causing enhanced httproteolysis, indicating that GIT-1 distribution and function may contribute to Huntington disease pathology(4).