Calnexin-NT 多克隆抗体: FITC
英文名称: Calnexin-NT Polyclonal Antibody: FITC
型号:null    抗体货号: SPC-127B-FITC
价格:请致电:010-57128832,18610462672
品牌: 加拿大    产品商标: stressmarq

Calnexin, an abundant ~90kDa integral protein of the endoplasmic reticulum, is also referred to as IP90, p88 and p90 (1). It consists of a large 50kDa N-terminal calcium-binding luminal domain, a single transmembrane helix and a short acidic cytoplasmic tail (2, 3). Unlike its ER counterparts which have a KDEL sequence on their C-terminus to ensure ER retention (4), calnexin has positively charged cytosolic residues that do the same thing (3).Most ER proteins act as molecular chaperones and participate in the proper folding of polypeptidesand their assembly into mulit-subunit proteins. Calnexin together with calreticulin, plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their mono-glycosylated glycans (5, 6). Calnexin has also been shown to associate with the major histocompatibility complex class I heavy chains, partial complexes of the T cell receptor and B cell membrane immunoglobulin (7).