重组人 Mn SOD 蛋白
英文名称: Recombinant Human Mn SOD
型号:null    产品货号: SPR-131A
价格:请致电:010-57128832,18610462672
品牌: 加拿大
试剂级别: affinity purified

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme present in almost every cell in the body (3). It works by catalyzing the dismutation of the superoxide radical O2ˉ to O2 and H2O2, which are then metabolized to H2O and O2 by catalase and glutathione peroxidase (2, 5). In general, SODs play a major role in antioxidant defense mechanisms (4).There are two main types of SOD in mammalian cells. One form (SOD1) contains Cu and Zn ions as a homodimer and exists in the cytoplasm. The two subunits of 16 kDa each are linked by two cysteines forming an intra-subunit disulphide bridge (3). The second form (SOD2) is a manganese containing enzyme and resides in the mitochondrial matrix. It is a homotetramer of 80 kDa. The third form (SOD3 or EC-SOD) is like SOD1 in that it contains Cu and Zn ions, however it is distinct in that it is a homotetramer, with a mass of 30 kDA and it exists only in the extracellular space(8). SOD3 can also be distinguished by its heparin-binding capacity (1). 

it-gradient(linear,left top,left bottom,from(#D1EA74),to(#77A819));" align="center" border=0 cellPadding=0 cellSpacing=0> alternatively spliced isoforms. The gene encoding CCDC51 maps to human chromosome 3, which is made up of about 214 million bases encoding over 1,100 genes. Notably, there is a chemokine receptor gene cluster and a variety of human cancer related loci on chromosome 3. Particular regions of the chromosome 3 short arm are deleted in many types of cancer cells. Key tumor suppressing genes on chromosome 3 encode apoptosis mediator RASSF1, cell migration regulator HYAL1 and angiogenesis suppressor SEMA3B. Marfan Syndrome, porphyria, von Hippel-Lindau syndrome, osteogenesis imperfecta and Charcot-Marie-Tooth Disease are a few of the numerous genetic diseases associated with chromosome 3.

Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).

Database links:
UniProtKB/Swiss-Prot: Q96ER9.2
Entrez Gene: 79714 Human
Entrez Gene: 66658 Mouse
Entrez Gene: 316008 Rat
SwissProt: Q96ER9 Human
SwissProt: Q3URS9 Mouse
SwissProt: Q5PPN7 Rat
Unigene: 187657 Human


CCDC51,卷曲螺旋结构域蛋白51抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.