DACT3,Dapper3蛋白抗体
英文名称: Anti-DACT3 antibody
型号:null    抗体货号: HZ-11837R
价格:请致电:010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

DACT3,Dapper3蛋白抗体

产品编号HZ-11837R
英文名称DACT3
中文名称Dapper3蛋白抗体
别 名Antagonist of beta-catenin Dapper homolog 3; Arginine rich region 1; Arginine rich region 1 protein; Arginine-rich region 1 protein; Dact3 antibody; DACT3_HUMAN; Dapper antagonist of beta catenin 3; Dapper antagonist of beta catenin homolog 3 (Xenopus laevis); Dapper homolog 3; Dapper3; Dpr3 antibodyRRR1; RRR1; Thymus expressed gene 3 like.
说 明 书0.1ml 0.2ml
研究领域肿瘤 神经生物学 信号转导 干细胞
抗体来源Rabbit
克隆类型Polyclonal
交叉反应Human, Mouse, Rat, Pig, Cow, Sheep,
DACT3,Dapper3蛋白抗体产品应用ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量65kDa
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human DACT3
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
DACT3,Dapper3蛋白抗体PubMedPubMed
产品介绍background:
Dapper3 is a 629 amino acid protein and mammalian homolog of the Xenopus laevis protein dapper. As a member of the dapper family, Dapper3 plays a role in postnatal brain development and contains a C-terminal PDZ-binding motif that facilitates interaction with the PDZ domains of DSH (Dishevelled) family proteins. As the predominant dapper family member found in adult brain, Dapper 3 localizes to hippocampus, Purkinje cell layer and every layer of the dorsal forebrain and cerebral cortex and is also found in the developing murine central nervous system. Dapper3 is also expressed in uterus, ventral somites, branchial arch mesenchyme, aortic sac, aortic arches, limb bud mesenchyme and craniofacical mesenchyme. Mapping to human chromosome 19q13.32, Dapper3 has been identified as a negative regulator of Wnt/beta-catenin signaling in colorectal cancer.

Function:
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

Subunit:
Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.

Similarity:
Belongs to the dapper family.

Database links:
UniProtKB/Swiss-Prot: Q96B18.2

DACT3,Dapper3蛋白抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

es. Within the heart, specifically expressed in myocytes.

Post-translational modifications:
Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.
Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation.

Caspase-9,活化半胱胺酸蛋白酶蛋白-9抗体Similarity:
Belongs to the peptidase C14A family.
Contains 1 CARD domain.

Gene ID:
842

Database links:
Entrez Gene: 842 Human
Entrez Gene: 12371 Mouse
Entrez Gene: 58918 Rat
Omim: 602234 Human
SwissProt: P55211 Human
SwissProt: Q4FJK5 Mouse
SwissProt: Q920G4 Rat
Unigene: 329502 Human
Unigene: 88829 Mouse
Unigene: 32199 Rat


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Caspase-9半胱氨酸蛋白酶家族成员之一,又称ICE-Lap6(ICE Like apoptotease 6)参与细胞凋亡过程和细胞因子的加工过程,在许多胚胎和***组织中都有分布。此抗体主要用于肿瘤研究。