Follistatin,卵泡抑素抗体
英文名称： Anti-Follistatin antibody
型号:null    抗体货号： HZ-1773R
价格:请致电：010-57128832,18610462672
品牌: 中国/美国    产品商标: hzbscience

Follistatin,卵泡抑素抗体

产品编号HZ-1773R
英文名称Follistatin
中文名称卵泡抑素抗体
别 名Activin binding protein; FS; Follistatin; Activin-binding protein; FS; fst; FST_HUMAN; Human follistatin gene; follistatin isoform FST344 precursor; FST344; follistatin isoform FST317 precursor; FST317; FST_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 生长因子和***
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
Follistatin,卵泡抑素抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量38kDa
细胞定位分泌型蛋白
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human Follistatin
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Follistatin,卵泡抑素抗体PubMedPubMed
产品介绍background:
Follistatin is a single-chain gonadal protein that specifically inhibits follicle-stimulating hormone release. The single FST gene encodes two isoforms, FST317 and FST344 containing 317 and 344 amino acids respectively, resulting from alternative splicing of the precursor mRNA. There is evidence linking polycystic ovary syndrome and follistatin.
Follistatin binds directly to activin and functions as an activin antagonist. It specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone.

Subunit:
Monomer (Potential).

Subcellular Location:
Secreted.

Tissue Specificity:
Isoform 1 is the predominant isoform in serum but is undetectable in follicular fluid.

Follistatin,卵泡抑素抗体Similarity:
Contains 3 follistatin-like domains.
Contains 3 Kazal-like domains.
Contains 1 TB (TGF-beta binding) domain.

Gene ID:
10468

Database links:
Entrez Gene: 396119 Chicken
Entrez Gene: 327681 Cow
Entrez Gene: 10468 Human
Entrez Gene: 14313 Mouse
Entrez Gene: 445002 Pig
Entrez Gene: 24373 Rat
Omim: 136470 Human
SwissProt: Q90844 Chicken
SwissProt: P50291 Cow
SwissProt: P19883 Human
SwissProt: P47931 Mouse
SwissProt: P10669 Pig
SwissProt: P21674 Rat
Unigene: 9914 Human
Unigene: 4913 Mouse
Unigene: 162557 Rat

Follistatin,卵泡抑素抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

卵泡抑素是一种新发现的生殖调节因子,参与卵巢颗粒细胞分化、黄体形成、卵泡闭锁,胚胎发育及胎盘功能的调节，FST的合成分泌也受垂体促性腺***、卵巢甾体***(孕***)、糖蛋白***(抑制素、激活素)等多因子调节。

tids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites and could be sites of replication fork stalling. The foci are frequently interlinked through BLM-associated ultra-fine DNA bridges. Following aphidicolin treatment, targets chromatid gaps and breaks.

Tissue Specificity:
Highly expressed in germinal center cells of the spleen, tonsil, and reactive lymph nodes, and in the proliferating basal layer of squamous epithelium of tonsil, esophagus, oropharynx, larynx and cervix. Expressed in cytotrophoblastic cells of the placenta and exocrine cells of the pancreas (at protein level). Highly expressed in testis, where expression is restricted to maturing spermatocytes.

phospho-FANCD2 (Ser222),***酸化FANCD2抗体Post-translational modifications:
Monoubiquitinated on Lys-561 during S phase and upon genotoxic stress by FANCL in complex with E2 ligases UBE2T or UBE2W (isoform 1 and isoform 2). Deubiquitinated by USP1 as cells enter G2/M, or once DNA repair is completed. Monoubiquitination requires the joint intervention of the FANC core complex, including FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, and FANCM, and proteins involved in cell cycle checkpoints and DNA repair, including RPA1, ATR, CHEK1 and BRCA1, and is mediated by FANCL/PHF9. Ubiquitination is required for binding to chromatin, interaction with BRCA1, BRCA2 and MTMR15/FAN1, DNA repair, and normal cell cycle progression, but not for phosphorylation on Ser-222 or interaction with MEN1.
Phosphorylated in response to various genotoxic stresses by ATM and/or ATR. Upon ionizing radiation, phosphorylated by ATM on Ser-222 and Ser-1404. Phosphorylation on Ser-222 is required for S-phase checkpoint activation, but not for ubiquitination, foci formation, or DNA repair. In contrast, phosphorylation by ATR on other sites may be required for ubiquitination and foci formation.
Defects in FANCD2 are a cause of Fanconi anemia complementation group D type 2 (FANCD2) [MIM:227646]. A disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia. It is associated with cardiac, renal and limb malformations, dermal pigmentary changes, and a predisposition to the development of malignancies. At the cellular level it is associated with hypersensitivity to DNA-damaging agents, chromosomal instability (increased chromosome breakage) and defective DNA repair.

Gene ID:
2177

Database links:
Entrez Gene: 2177 Human
Entrez Gene: 211651 Mouse
Entrez Gene: 312641 Rat
Omim: 613984 Human
SwissProt: Q9BXW9 Human
SwissProt: Q80V62 Mouse
SwissProt: Q6IV68 Rat
Unigene: 208388 Human
Unigene: 160061 Mouse
Unigene: 203979 Rat

phospho-FANCD2 (Ser222),***酸化FANCD2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FANCD2是一种在DNA损伤修复过程中起重要作用的蛋白质，其作作用在于通过修补DNA损伤或促进有缺陷细胞**来预防癌症，所以低水平的FANCD2会导致DNA损伤，从而诱发癌症。
有学者认为:FANCD2是个重要的抵御癌症蛋白，而香烟会破坏它的制造过程当然还可能包含有其他蛋白，但至少FANCD2是关键的主要蛋白，因为含有非常高水平FANCD2的细胞能够抵御香烟的毒害作用。
FANCD2蛋白在保护肺细胞抵御香烟威胁时有重要作用；FANCD2蛋白是负责修复受损DNA的重要蛋白，而受香烟燃烧产生的烟雾影响的肺细胞很少产生FANCD2蛋白，没有FANCD2蛋白，受损的DNA导致肿瘤细胞增殖扩散并无法控制。研究结果表明，FANCD2蛋白在保护肺细胞抵御香烟威胁时有重要作用，也可解释为什麽香烟燃烧产生的烟雾对肺细胞具有如此大的危害。 　

产品图片
Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; 
Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
Incubation: Anti-phospho-FANCD2(Ser222) Polyclonal Antibody, Unconjugated(HZ-3015R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining