ECE2,内皮素转化酶2抗体

产品编号HZ-1753R
英文名称ECE2
中文名称内皮素转化酶2抗体
别 名ECE2; MGC78487; ECE 2; Endothelin converting enzyme 2; Hypothetical protein MGC2408; KIAA0604; MGC17664; ECE2_HUMAN.
说 明 书0.1ml 0.2ml
研究领域免疫学 神经生物学 转录调节因子 Alzheimer's
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, Mouse, Rat,
ECE2,内皮素转化酶2抗体产品应用WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量80-100kDa
细胞定位细胞浆 细胞膜
性 状Lyophilized or Liquid
浓 度1mg/1ml
免 疫 原KLH conjugated synthetic peptide derived from human ECE2
亚 型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
ECE2,内皮素转化酶2抗体PubMedPubMed
产品介绍background:
Endothelin-converting enzyme 2 (ECE2) converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May limit beta-amyloid peptide accumulation in brain. May also have methyltransferase activity. Expressed at high levels in central nervous system. Expressed in adrenal glands, ovary and uterus, and at low levels in heart.

Subcellular Location:
Golgi apparatus membrane; Single-pass type II membrane protein (By similarity). Cytoplasmic granule membrane; Single-pass type II membrane protein (By similarity).

Tissue Specificity:
Expressed in brain. Strongly down-regulated in inferior parietal lobe from Alzheimer disease patients (at protein level).

Similarity:
In the N-terminal section; belongs to the methyltransferase superfamily.
In the C-terminal section; belongs to the peptidase M13 family.

Gene ID:
9718

Database links:
Entrez Gene: 281134 Cow
Entrez Gene: 9718 Human
Omim: 610145 Human
SwissProt: Q10711 Cow
SwissProt: O60344 Human
Unigene: 146161 Human

ECE2,内皮素转化酶2抗体Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.