Other Notes

air sensitive

Legal Information

Sold for research purposes under agreement from Pfizer Inc.

Biochem/physiol Actions

Tigecycline is a broad spectrum glycylcycline antibiotic. Tigecycline is bacteriostatic, that inhibits protein synthesis by binding to the 30S ribosomal subunit of bacteria and thereby blocking entry of Aminoacyl-tRNA into the A site of the ribosome during prokaryotic translation. Tigecycline is active against resistant strains of gram-positive and gram-negative bacteria, avoiding the two most common mechanisms of resistance to the tetracycline antimicrobials: tetracycline efflux pump proteins and ribosomal protection proteins.

assay	≥98% (HPLC)
form	powder
optical activity	[α]/D -160 to 170°, c = 0.15 in methanol
color	off-white to yellow-brown
solubility	DMSO: ≥3 mg/mL (warmed)
storage temp.	2-8°C