| Name 名称 | Pathway/Target 通路/靶点 | Package 包装规格 | Price(RMB) 价格(人民币) | Cat# 货号 | Functions 功能 |
| A769662 | AMPK/mTOR | 10 mg | 1190 | C2769-10 C2769-10s | A769662 is a potent, reversible AMP-activated protein kinase (AMPK) activator. Useful for both cell survival and cell proliferation studies. A769662是一种高效的可逆的AMPK激活剂。可用于细胞存活和细胞增殖方面的研究。 |
| A83-01 | TGF-β | 2 mg | 890 | C2831-2 C2831-2s | A83-01 inhibits the TGF-β-induced epithelial-to-mesenchymal transition via the inhibition of Smad2 phosphorylation. A83-01 has been used to generate rat and human iPS cells towards a mouse ES cell like self-renewal state. A83-01通过抑制Smad2***酸化来抑制TGF-β诱导的上皮-间质转分化。用于使大鼠和人类的iPS细胞倾向于类似小鼠的ES细胞的自我更新状态。 |
| BEZ235 | PI3K/mTOR | 2 mg | 490 | C2392-2 C2392-2s | BEZ235 is a dual inhibitor of the PI3K and the downstream mTOR. It inhibits the activation of the downstream effectors Akt, S6 ribosomal protein, and 4EBP1 in breast. BEZ235是一个针对PI3K和下游mTOR的双重抑制剂。它可以抑制下游效应分子Akt，S6核糖体蛋白以及4EBP1。 |
| BIX-01294 | Epigenetic-G9a HMT | 5 mg | 890 | C2491-5 C2491-5s | BIX-01294 is a selective inhibitor of G9a histone methyl transferase. It enhances reprogramming efficiency of neural progenitor cells to the same levels as when Oct4, Klf4, Sox2 and c-Myc were introduced to somatic cells for generation of iPS cells. BIX-01294是G9a组蛋白甲基转移酶的抑制剂。能够增强神经前体细胞的重编程效率，使其能够达到体细胞转入Oct4, Klf4, Sox2 和c-Myc产生iPS细胞同等效率。 |
| CHIR99021 | Wnt/GSK-3β | 2 mg | 2090 | C2447-2 C2447-2s | CHIR99021 is the most selective inhibitor of glycogen synthase kinase 3β reported so far. It worked in long term expansion of murine embryonic stem cells in conjunction with MEK/MAPK inhibitor PD0325901 and FGFR inhibitor SU5402. CHIR99021是目前为止报道的GSK-3β的选择性最好的抑制剂。与MEK/MAPK 抑制剂PD0325901和FGFR抑制剂SU5402一起用于小鼠胚胎干细胞的长期扩增中。 |
| CP-690550 | JAK | 2 mg | 790 | C2716-2 C2716-2s | CP-690550 is a potent and selective JAK inhibitor. In cellular assays it potently inhibits signaling through JAK1 and JAK3 with 5-100 fold selectivity over JAK2. CP-690550是一个JAK的高效的选择性抑制剂。在细胞实验中它可以通过比抑制JAK2高出5-100倍的效率抑制JAK1和JAK3，以此高效抑制信号传导。 |
| Cyclopamine | Hedgehog/Smo | 2 mg | 1290 | C2925-2 C2925-2s | Cyclopamine is a specific Inhibitor of hedgehog (Hh) signaling via direct inhibition of Smoothened. Cyclopamine could be used to induce stem cell differentiation towards definitive endoderm pancreatic islet cells, and to inhibit stem-like cancer cell proliferation and block tumor engraftment. Cyclopamine是hedgehog (Hh)的特异性抑制剂，通过直接抑制Smoothened 发挥作用。Cyclopamine可以用来诱导干细胞向特定的内胚层胰岛细胞分化，并能抑制类干细胞样癌症细胞的增殖和肿瘤的移植。 |
| DAPT | Notch/ γ‐secretase | 5 mg | 1090 | C3178-5 C3178-5s | DAPT is a γ-secretase inhibitor and indirectly an inhibitor of Notch. Due to the involvement of the Notch pathway in the development of both the nervous system and pancreas, DAPT is useful in modulating Notch activity in embryonic stem cell differentiation studies. DAPT是一种γ分泌酶抑制剂， Notch的间接抑制剂。DAPT参与了神经系统和胰腺发育过程中的Notch通路。所以通过它调节Notch活性而可以用于胚胎干细胞的分化过程的研究。 |
| Hh-Ag1.5 | Hedgehog/ Smo | 2 mg | 1790 | C4412-2s | Hh-Ag1.5 is a small-molecule chemical agonist of Smoothened receptor and is an activator of sonic hedgehog signaling. It has agonist activity with EC50 = 1 nM. Hh-Ag1.5是一种Smoothened受体的小分子化学激动剂。Sonic Hedgehog信号传导的激活剂。它的激动剂活性的EC50值为1nM |
| INCB018424 | JAK | 2 mg | 1090 | C4622-2s | INCB018424 is a selective inhibitor of JAK1 and 2, currently in clinical trials to treat myelofibrosis. It potently inhibits JAK1, JAK2 in enzyme assays. It has IC50 of 280 nM in cytokine-stimulated whole blood assays. INCB018424是JAK1和2的选择性抑制剂，目前在临床中用于骨髓纤维变性的治疗。酶实验表明它能高效抑制JAK1,JAK2。在细胞因子刺激的全血实验中它的IC50为280nM。 |
| LDE225 | Hedgehog/ Smo | 2 mg | 1390 | C5332-2 C5332-2s | LDE225 is a potent and specific Smo inhibitor. It has been shown to inhibit Hh-and Smo-dependent proliferation in vivo. It induces almost complete regression of preformed basaloid lesions at 1.5uM. LDE225是一种高效且特异的Smo抑制剂。in vivo实验显示它可以抑制Hh和Smo依赖的增殖。1.5uM几乎可以完全抑制基底细胞样病变。 |
| LDN-193189 | BMP | 2 mg | 2190 | C5361-2 C5361-2s | LDN-193189 is a highly potent BMP inhibitor, prevents Smad1, Smad5, and Smad8 phosphorylation through inhibition of BMP type I receptors ALK2 and ALK3. LDN-193189是BMP的高效抑制剂。通过抑制BMP I型受体ALK2和ALK3来阻止Smad1, Smad5和Smad8的***酸化。 |
| PD0325901 | MEK1/2 | 2 mg | 2190 | C7303-2 C7303-2s | PD0325901 is a selective inhibitor with IC50 about 1nM against MEK1 and MEK2. When using with GSK-3β inhibitor CHIR99021, PD0325901 could prevent cell differentiation and sustain ES cell self-renewal. PD0325901是一个MEK1和MEK2的选择性抑制剂，IC50大概为1nM。当和GSK-3β 抑制剂CHIR99021一起使用的时候，它可以阻止细胞分化，维持ES细胞的自我更新。 |
| PS48 | PDK1 | 5 mg | 790 | C7748-5 C7748-5s | PS48 is an activator of phosphoinositide-dependent protein kinase 1 (PDK1). It has been used to enhance reprogramming of neonatal human epidermal keratinocytes (NHEKs). PS48是一个PDK1的激活剂。用来增强人新生儿表皮角化细胞(NHEKs)的重编程过程。 |
| Pyrintegrin | | 1 mg | 1990 | C7974-1 C7974-1s | Pyrintegrin was identified to promote human embryonic stem cell (hESC) survival by >30-fold. This dramatic increase is attributed to the protection of the cell surface protein e-cadherin from damage. Pyrintegrin能够促进人的胚胎干细胞（hESC）成活率30倍以上。主要原理是它能保护细胞表面的e-cadherin免于损伤。 |
| Reversine | | 2 mg | 690 | C7383-2 C7383-2s | Reversine is a selective A3 adenosine receptor antagonist. It could induce differentiated myogenic-linage committed cells to become multipotent mesenchymal progenitor cells. Reversine是一种A3腺苷受体拮抗剂。能够诱导分化的肌源性定向细胞成为多能间充质祖细胞。 |
| RO4929097 | Notch/ γ‐secretase | 2 mg | 1590 | C7649-2 C7649-2s | RO4929097 is a potent and selective inhibitor of γ-secretase (IC50=4nM). It inhibits Notch processing in tumor cells as measured by the reduction of intracellular Notch expression. RO4929097是一种强效的γ分泌酶选择性抑制剂(IC50=4nM)。它可以抑制Notch在肿瘤细胞中的Notch加工，减少细胞间Notch的表达量。 |
| SB431542 | TGF‐β | 5 mg | 890 | C7243-5 C7243-5s | SB-431542 is a selective and potent inhibitor of activin receptor-like kinase (ALK). It blocks Smad signaling and suppresses renewal in embryonic and iPS cells, and promotes differentiation and enhances reprogramming efficiency when used with MEK inhibitor PD0325901. SB-431542是ALK的选择性高效抑制剂。它可以阻滞Smad信号，抑制胚胎干细胞和iPS细胞的自我更新，促进分化。与MEK抑制剂PD0325901一起使用可以增强重编程的效率。 |
| SF1670 | pTEN | 2 mg | 2190 | C7316-2 C7316-2s | SF1670 is a selective pTEN inhibitor (IC50=2 µM). PTEN-mTOR pathway is critical for controlling the regenerative capacity of corticospinal neurons. Negative regulation of PTEN activity through deletion or inhibition enhances the regenerative ability of adult corticospinal neurons. SF1670 是一个pTEN的选择性抑制剂(IC50=2 µM)。PTEN-mTOR是控制皮质脊髓神经元的再生能力的关键通路。通过基因敲除或者抑制可以负调控pTEN的活性，从而增强成体皮质脊髓神经元的再生能力。 |
| SR1 | | 1 mg | 2190 | C7710-1 C7710-1s | StemRegenin1 (SR1) is a selective small molecule that promotes self-renewal of human hematopoietic stem cells in culture. SR1 is anantagonist of the aryl hydrocarbon receptor. StemRegenin1 (SR1)是能选择性促进体外培养的人的造血干细胞的自我更新的一种小分子化合物。SR1是芳香烃受体的拮抗剂。 |
| Thiazovivin | ROCK | 1 mg | 1690 | C8442-1 C8442-1s | Thiazovivin dramatically improves the survival of hESCs upon trypsinization. It improves reprogramming efficiency by more than 200-fold in combination with inhibitors of TGF-β receptor (A83-01) and MEK pathway (PD0325901). Thiazovivin能够显著提高胰酶消化的hESC细胞的存活率。与TGF-β和MEK途径抑制剂（A83-01，PD0325901）联合使用可以促进重编程效率提高200倍以上。 |
| Wnt-C59 | Wnt | 2 mg | 1090 | C7641-2 C7641-2s | Wnt-C59 is a potent Wnt signaling modulator. It has IC50 <0.11 nM in Wnt-Luc reporter assay for Wnt pathway inhibition. Wnt-C59 prevents palmitylation of Wnt proteins by Porcupine, thereby blocking Wnt secretion and activity. Wnt-C59是一种高效的Wnt信号调控因子。Wnt-Luc受体抑制实验显示它对Wnt途径的抑制的IC50<0.11nM。Wnt-C59阻止Porcupine 造成的Wnt蛋白的棕榈酰化，并因此阻止Wnt的分泌和活性。 |
| XAV939 | Wnt | 2 mg | 1590 | C9289-2 C9289-2s | XAV939 selectively inhibits β-catenin-mediated transcription. It stimulates β-catenin degradation by stabilizing axin through inhibition poly-ADP-ribosylating enzymes tankyrase 1 and tankyrase 2. XAV939可以选择性抑制β-catenin参与的转录。它可以抑制聚(ADP-核糖)聚合酶tankyrase 1和2，从而稳定axin，促进β-catenin的降解。 |
| Y-27632 | ROCK | 2 mg | 1090 | C9127-2 C9127-2s | Y-27632 is a specific inhibitor of the ROCK family. It prevents dissociation-induced apoptosis, and enhances the survival and cloning efficiency of dissociated hES cells without affecting their self-renewal properties or pluripotency. Y-27632是一种ROCK家族的特异性抑制剂。它阻止hESC的分离引起的凋亡，增强hESC分离的的存活以及克隆生成能力，同时不会影响到hESC的自我更新能力和多能性。 |