Catalog # CHIR-02; CHIR-10; CHIR-50
Description CHIR99021 (CT99021) is a glycogen synthase kinase 3
(GSK3
) inhibitor
with IC50 less than 10 nM. Compared to other GSK-3 inhibitors, CHIR-
99201 does not exhibit cross-reactivity against cyclin-dependent kinases
(CDKs) with 350-fold selectivity toward GSK-3
compared to CDKs .
Ref: Tighe A et al. BMC Cell Biol. 2007 Aug 14;8:34Formulation Powder
Reconstitution Before reconstitution, we recommend a brief spin to drive down any
material dislodged from the bottom of the tube. The compound is soluble
in DMSO.
Stability The powder is stable for at least 2 year if stored at -20 degree C. The
dissolved compound is stable for at least 1 month at 4 degree C, but should
be stored in aliquots at -20 degree C for longer term. Protect from light.
Purity Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR
data available upon request.
Biological Activity In a cell-based assay measuring the activation of the TCF reporter gene, this
compound gives EC50 of 50 nM.M.W.: 465.34
Formula: C22H18Cl2N8
Solubility: DMSO
CAS No.: 252917-06-9