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         ScienCell研究实验室生产的原代细胞、原代细胞专用培养基都经过了严格的质量控制，细胞纯度可达98％。其中包括21种人体正常细胞系统，90多种不同细胞类型。大多数细胞在全球唯有ScienCell实验室能够成功分离，产品质量过硬。确保了实验结果的重复性和连贯性。
 

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产品：人细胞纤连蛋白

货号：8488

Description

Fibronectin is a multi-domain glycoprotein composed of an array ofmultiple repeated modular structures. Cellular fibronectin, an adhesionglycoprotein of the extracellular matrix, exists as a dimer with amolecular mass of ~ 550 kDa. This structure is composed of twoheterodimers, the A chain and the B chain containing the type IIIconnecting segment region. Cellular fibronectin differs from plasmafibronectin by the presence of additional polypeptide segments and itscapacity to specifically regulate morphology and growth of attachedcells including stem cells. Multiple domains of fibronectin show bindingaffinities for collagen, fibrin, heparin, and specific cell membranereceptors including integrins, as well as modulate cell adhesion.Fibronectin matrix assembly is essential for normal development andcontributes to the generation of tumor metastases.

ScienCell Human Cellular Fibronectin is produced from human fibroblastsmaintained in serum-free media and then purified biochemically. This issupplied sterile in CAPS saline buffer.


Storage

It is recommended to store the product as single use aliquots at -80°C.Thawing should be done slowly at 2-8°C with no agitation. Material thatfails to dissolve can be removed by centrifugation. Avoid repeatingfreeze/thaw cycles.


Reference

1. Yamada KM and Akiyama SK (1984). In Methods for preparation ofmedia, supplements and substrata for serum-free animal cell culture. pp.215-30. Alan R. Liss, Inc., New York.
2. Akiyama S et al. (1985). Fibronectin and fibronectin fragments inExtracellular Matrix: A Practical Approach, (New York), p. 183.
3. Potts JR and Campbell ID (1994). Fibronectin Structure and Assembly.Curr. Cell Bio, 6: 648-655.
4. Singh P, Schwarzbauer JE (2012). Fibronectin and stem celldifferentiation - lessons from chondrogenesis. J Cell Sci, 15: 3703-12.