Synonyms :

none

Description :

β-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. β-NGF is a potent neurotrophic factor that signals through its receptor β-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. β-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of murine β-NGF is a noncovalently disulfide-linked homodimer, of two 13.4 kDa polypeptide monomers (240 total amino acid residues). The three disulfide bonds are required for biological activity.

Catalog #:

450-34

Source :

E.coli

Purity :

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin Level :

Endotoxin level is less than 0.1 ng per μg (1EU/μg).

Biological Activity :

The ED₅₀ as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is < 1.0 ng/ml, corresponding to a specific activity of 1 x 10⁶ units/mg.

Selected References :

Selected List of References Citing This PeproTech Product

AA Sequence :

MSSTHPVFHM GEFSVCDSVS VWVGDKTTAT DIKGKEVTVL AEVNINNSVF RQYFFETKCR ASNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDEKQAAW RFIRIDTACV CVLSRKATRR G

PubMed Link :

NGF+AND+mouse

Country of Origin :

USA

Size A	5μg	$80
Size B	20μg	$195
Size C	1mg	$3000

Special Sizes:
Many products can be ordered in custom sizes. Please click here to contact Peprotech with your request.

Usage:
For Research Use Only. Not for use in diagnostic or therapeutic procedures.