重组人 R-Spondin-2 100ug
英文名称: Recombinant Human R-Spondin-2
型号:null    产品货号: 120-43
价格:请致电:010-57128832,18610462672
品牌: 美国

Recombinant Human R-Spondin-2

Catalog Number:
120-43
Synonyms:
Roof plate-specific, spondin-2, RSPO2
Description:
The R-Spondin (Rspo) proteins belong to the Rspo family of Wnt modulators. Currently, the family consists of four structurally related secreted ligands (Rspo 1-4), all containing furin-like and thrombospondin structural domains. The Rspo proteins can interact with the Frizzled/LRP6 receptor complex in a manner that causes the stabilization and resulting accumulation of the intracellular signaling protein, β-catenin. This activity effectively activates and increases the subsequent nuclear signaling of β-catenin. R-Spondin can also bind to the previously discovered G-protein coupled receptors, LGR-4 and LGR-5. Rspo/β-catenin signaling can act as an inducer of the transformed phenotype, and can also regulate the proliferation and differentiation of certain stem cell populations.  Recombinant human R-Spondin-2 is a 24.4 kDa protein consisting of 212 amino acid residues.  Due to glycosylation, R-Spondin-2 migrates at an apparent molecular weight of approximately 30.0 kDa by SDS PAGE analysis under reducing conditions.
AA Sequence:
ASYVSNPICK GCLSCSKDNG CSRCQQKLFF FLRREGMRQY GECLHSCPSG YYGHRAPDMN RCARCRIENC DSCFSKDFCT KCKVGFYLHR GRCFDECPDG FAPLEETMEC VEGCEVGHWS EWGTCSRNNR TCGFKWGLET RTRQIVKKPV KDTILCPTIA ESRRCKMTMR HCPGGKRTPK AKEKRNKKKK RKLIERAQEQ HSVFLATDRA NQ
Source:
CHO cells
Purity:
Greater than 95% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
R-Spondin-2 enhances BMP-2 mediated differentiation of MC3T3-E1 cells.
 
 
 
 
Research Interests:
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.