Description | Interferon-gamma (IFN-γ) is a multifunctional cytokine which is secreted primarily by activated NK cells and T cells. IFN-γ exerts a wide range of immunoregulatory activities and is considered to be the prototype proinflammatory cytokine. Originally characterized based on anti-viral activities, IFN-γ also exerts anti-proliferative, immunoregulatory, and proinflammatory activities. IFN-γ can upregulate MHC class I and II antigen expression by antigen-presenting cells. |
Synonyms | Interferon-γ, Immune interferon, Type II interferon, T cell interferon, Macrophage-activating factor (MAF), |
AA Sequence | MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFRGR RASQ |
Source | Escherichia coli. |
Molecular Weight | Approximately 16.9 kDa, a single non-glycosylated polypeptide chain containing 144 amino acids. |
Biological Activity | Fully biologically active. The specific activity determined by an anti-viral assay is no less than 2.0 x 10^7 IU/mg. |
Physical Appearance | White lyophilized powder. |
Formulation | Lyophilized from a 0.2μm filtered concentrated (1mg/ml) solution in PBS, pH 7.4. |
Endotoxin | < 1EU/μg of rhIFN-γ as determined by LAL method. |
Reconstitution | Reconstitute in sterile distilled water containing 0.1% BSA to a concentration of 0.1-1.0 mg/mL. |
Storage | Store at -20°C after receiving. Upon reconstitution, store at 2-8°C for up to one week. For maximal stability, aliquot and store at -20°C. Avoid repeated freeze/ thaw cycles. |
Usage | This product is for research use only. It is not approved for use in humans, animals, or in vitro diagnostic procedures. |