Recombinant Human IL-1α
Catalog Number:
AF-200-01A
Synonyms:
Hematopoietin-1, Lymphocyte-activating factor (LAF), Endogenous Pyrogen (EP), Leukocyte, Endogenous Mediator (LEM), Mononuclear Cell Factor (MCF)
Description:
IL-1α是一个非分泌促炎性细胞因子，可由多种细胞，包括单核细胞，组织巨噬细胞，角质形成细胞和其他上皮细胞产生。IL-1α和IL-1β结合同一受体，并具有类似的，即使不是完全相同的的生物学特性。这些细胞因子有广泛的活性，包括刺激胸腺细胞增殖，诱导IL-2释放，B细胞的成熟和增殖，FGF样的促有丝分裂活性以及刺激滑膜细胞释放前列腺素和胶原酶。 相反，IL-1β是一种分泌型的细胞因子。重组人IL-1α是一个分子量为18.0 kDa的蛋白质，由159个氨基酸残基组成。生产过程中所用的所有试剂均为非动物源性。
AA Sequence:
SAPFSFLSNV KYNFMRIIKY EFILNDALNQ SIIRANDQYL TAAALHNLDE AVKFDMGAYK SSKDDAKITV ILRISKTQLY VTAQDEDQPV LLKEMPEIPK TITGSETNLL FFWETHGTKN YFTSVAHPNL FIATKQDYWV CLAGGPPSIT DFQILENQA
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to stimulate the proliferation of mouse D10S cells. The expected ED50 is ≤0.001 ng/ml, corresponding to a specific activity of ≥1 x 109 units/mg.
Research Interests:
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.