Recombinant Rat Granulocyte Macrophage-Colony Stimulating Factor
型号:null    产品货号: CYT-395
价格:请致电:010-57128832,18610462672
品牌: 以色列

 

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Catalog Number:
AF-120-02
Synonyms:
BMP-2A
Description:

BMP-2是一种强效的诱导成骨细胞因子,能够通过具有骨传导性的载体如胶原蛋白和合成羟基***灰石诱导骨和软骨的形成。除了具有成骨活性,BMP-2在心脏形态形成中也有重要作用,并在多种其他组织中有表达,包括肺、肝、脾、前列腺、卵巢和小肠。有功能的BMP-2是由两个相同的含有114个氨基酸的多肽链(单体)通过单一的二硫键连接而成的26 kDa的蛋白。每个BMP-2单体是其前体多肽的C-末端部分,其中也包含了23个氨基酸的分泌信号肽序列和一个259个氨基酸的前肽。该前体二聚化后(也是二硫键连接的同型二聚体),前肽和成熟BMP-2配体之间的共价键由弗林蛋白酶型蛋白酶裂解。重组人BMP-2是分子量为26.0 kDa,由二硫键连接两条由115个氨基酸组成的肽链所形成的的同型二聚体蛋白。生产过程中所用的所有试剂均为非动物源性。

AA Sequence:
MQAKHKQRKR LKSSCKRHPL YVDFSDVGWN DWIVAPPGYH AFYCHGECPF PLADHLNSTN HAIVQTLVNS VNSKIPKACC VPTELSAISM LYLDENEKVV LKNYQDMVVE GCGCR
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 0.5-1.0 μg/ml.
 
 
 
 
Research Interests:
Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular Apoptosis Apoptosis
Bone, Skeletal, Cartilage Bone, Skeletal, Cartilage Proliferation Proliferation
Stem Cells & Differentiation Stem Cells & Differentiation TGF-β Superfamily TGF-β Superfamily
 
 
Country of Origin:
USA
Research Use Only. Not for use in diagnostic or therapeutic procedures.