Description		Monoclonal Antibody against Presenilin 2 (PS2)
Intended Use		**Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use.
Form		Tissue Culture Supernatant
Host		Mouse
Species Reactivity		Human (human and mouse sequences are identical, likely to interact with mouse)
IsoType		IgG1
Specificity		Mutations in the genes for presenilin 1 and 2 (PS1/PS2) are the causative factors for ~50% of early onset familial Alzheimer's disease. PS1 and PS2 are homologous transmembrane proteins and along with nicastrin form high molecular mass multimeric protein complexes involved in the intramembranous proteolysis of several proteins including beta amyloid precursor protein (β-APP) and Notch receptor. Absence of PS1 is associated with dramatic reductions in the levels of mature glycosylated nicastrin. In contrast, absence of PS2 is associated with only modest reductions in the levels of immature nicastrin. The PS2 monoclonal antibody was raised using a GST-fusion containing the complete N-terminal fragment of human PS2 (residues 1-87).
Uses		This antibody is effective in immunoblotting and immunocytochemistry (ICC).
Suggested Working Dilution		The optimal working dilution should be determined for each specific assay condition. Western blot: 1:50 ICC: neat
Storage		Store at -20°C. Upon initial thawing, apportion into working aliquots and store at -20°C. Avoid repeated freeze-thaw cycles to prevent denaturing the antibody. For long-term storage, keep the antibody at -80°C.
Warranty/Conditions		Covance products may not be resold or modified for resale without prior written approval.
Rev. Date		6/6/2007