polyclonal anti-human presenilin-2 protein n-terminal antiserum 英文名称: Polyclonal Anti-human Presenilin-2 Protein N-terminal Antiserum |
型号:null 产品货号: GPA007N |
价格:请致电:010-57128832,18610462672 |
品牌: 美国 |
The presenilin-2 (PS-2) gene was discovered on chromosome 1 and is responsible for an early onset form of autosomal dominant Alzheimer's disease (AD). The amino acid sequence is approximately 67% identical with that of the PS-1 protein. It also is a membrane protein that has regions where mutations have been identified in family members with AD. The gene sequence of PS-2 does not match any known human gene sequences, except for that of PS-1; but has been found to be a new class of aspartic-proteases. It has now been identified as one of the (-secretase proteases. Alzheimer’s disease (AD) is characterized by the progressive formation in the brain of insoluble amyloid plaques and vascular deposits consisting of the 4-kD amyloid $-peptide (A$). A$ generation is initiated by proteolytic cleavage of the amyloid precursor protein (APP) at the N-terminal of A$ by $-secretase (BACE). The A$ peptide is then released by proteolytic cleavage at its C-terminus by g-secretase (presenilins). Because both these proteases are prime candidates for therapeutic intervention, an intense search has been underway to identify these two enzymes. A goat antiserum to a synthetic peptide that corresponds to amino acids 31-47 of the N-terminus of human PS-2 protein is currently available. This This antiserum was produced using proprietary methodology whereby the peptide is attached to a carrier that elicits minimal immunoreactivity so that the antiserum has a higher degree of specificity for the peptide. Since there is no overwhelming production of interfering antibodies to the carrier, this antiserum can routinely be used without further purification. Pseud-Immune™ control immune serum (Cat no. GPA018E) from a mock immunized animal is available to be used in conjunction with this antibody as well as the immunizing peptide (Cat no. HSP007N), which can be used to neutralize immunoreactivity. |