英文名称： Purified Monoclonal Antibody against Estrogen Receptor
| Description |  | Purified Monoclonal Antibody against Estrogen Receptor (CO1531) (Formerly Signet Catalog Nos: 670-01, 670-16 L1 Predilute, 670-26 L2 Predilute) |
| Intended Use | | **Research Use Only (RUO)** This product is sold for laboratory research use only, not for human or in-vivo use. |
| Clone | | CO1531 |
| Form | | Purified Antibody (in 0.01M PBS + 0.1% NaN3 + 1% BSA) |
| Host | | Mouse |
| Species Reactivity | | Human |
| IsoType | | IgG2a |
| Specificity | | Monoclonal Estrogen Receptor (ER) antibody clone CO1531 is directed against the beta form of estrogen receptor. Like other steroid hormone receptors, Estrogen Receptors are intracellular proteins. Estrogen Receptors play an important role in regulating mammary gland growth and differentiation. Breast tumors that are ER positive may also show a more favorable response to anti-estrogen therapies. Concentrated Format: SIG-3670-1000 [1 mL] Prediluted Formats: SIG-3670-16 [6 mL] is ready to use with Peroxidase Anti-Peroxidase detection systems. SIG-3670-26 [6 mL] is ready-to-use with biotin-based detection systems such as USA Ultra Streptavidin Detection (SIG-32250) or with ACUITYAdvanced Biotin Free Polymer Detection System. |
| Uses | | This antibody is effective in immunohistochemistry (IHC). |
| Suggested Working Dilution | | The optimal working dilution should be determined for each specific assay condition.
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| Notes | | Positive tissue (human): Breast cancer tissue |
| Storage | | Store between 2-8°C. |
| References | | Schultz J, et al. Differential modulation of DNA conformation by estrogen receptors α and β. J Biol Chem 277(10): 8702-8707, 2002. |
| Warranty/Conditions | | Covance products may not be resold or modified for resale without prior written approval. |
| Rev. Date | | 3/17/2009 |