Monoclonal Antibody against Synuclein-α
英文名称： Monoclonal Antibody against Synuclein-α
型号:null    产品货号： MMS-530R
价格:请致电：010-57128832,18610462672
品牌: usa

DescriptionSynuclein-α, Monoclonal Antibody - NEUROSCIENCEMonoclonal Antibody against Synuclein-α
CloneSyn 204
FormAscites
HostMouse
Species ReactivityHuman
IsoTypeIgG2a
[Ab]Synuclein-α, Monoclonal Antibody - NEUROSCIENCE2-3 mg/mL
SpecificitySynuclein-α, Monoclonal Antibody - NEUROSCIENCESynucleins are small soluble proteins expressed primarily in neural tissues and in certain tumors. The family includes 3 known proteins, alpha synuclein, beta synuclein and gamma synuclein. All synucleins have in common a highly conserved alpha helical lipid binding motif with similarity to the class-A2 lipid binding domains of the exchangeable apolipoproteins. The alpha and beta synuclein proteins are found primarily in brain tissue, where they are seen mainly in pre-synaptic terminals. Alpha synuclein is believed to be a major component of Lewy bodies in Parkinson's disease. Mutations in alpha synuclein are associated with rare familial cases of early onset Parkinson¡¯s disease, Alzheimer¡¯s disease and several other neurodegenerative illnesses. Syn 204 was raised using recombinant alpha synuclein and recognizes residues 1-130 of alpha synuclein.
UsesSynuclein-α, Monoclonal Antibody - NEUROSCIENCEThis antibody is effective in immunoblotting, immunoprecipitation and immunohistochemistry.
Suggested Working DilutionSynuclein-α, Monoclonal Antibody - NEUROSCIENCEThe optimal working dilution should be determined for each specific assay condition. This antibody is sold for laboratory research use only, not for human or in-vivo use. Covance antibodies may not be resold or modified for resale without prior written approval.
  • Western blot: 1:1,000
StorageSynuclein-α, Monoclonal Antibody - NEUROSCIENCEStore at -20°C. It is suggested that the total volume be divided into useable aliquots upon initial thaw.
ReferencesYazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron 45:847-859, 2005.

Giasson BI, Jakes R, Goedert M, Duda JE, Leight S, Trojanowski JQ, Lee VM. A panel of epitope-specific antibodies detects protein domains distributed throughout human alpha-synuclein in Lewy bodies of Parkinson's disease. J. Neurosci. Res. 59(4):528-533, 2000.
Warranty/ConditionsSynuclein-α, Monoclonal Antibody - NEUROSCIENCECovance products may not be resold or modified for resale without prior written approval.
Rev. DateSynuclein-α, Monoclonal Antibody - NEUROSCIENCE1/1/2004