CDK9 Gene Description cyclin-dependent kinase 9 (CDC2-related kinase) Alternative Names TAK; C-2k; CDC2L4; PITALRE Molecular Weight 45 kDa Summary The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/PTEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS.1

Western blot data of siRNA transfection experiment. A549 cells were lysed 72 hours after transfection. Cells were transfected with Transfection Reagent alone (Lane 1), 100nM ON-TARGETplus siCONTROL Non-Targeting Pool (Lane 2), or 100nM ONTARGETplus CDK9 siRNA (Lane 3). Western blot data for GAPDH is included as a control for equal protein loading.

Special Notes
*siRNA targets Human gene product.

Product #	Description	Pkg. Size
82340	Anti-CDK9 Protein Antibody	120 µl