Highlights:- Irreversibly crosslink reduced cysteine by flexible PEG/PEO spacer arms
- Polyethylene glycol spacer arms help maintain conjugate solubility
- Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
- PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
- Ideal for small molecule or peptide conjugations
- Maleimides react with –SH groups at pH 6.5-7.5, forming stable thioether linkages
- Reactive groups: maleimide (homobifunctional)
- Reactive toward: sulfhydryl groups
| Alternative Names for BM(PEG)n:- Bismaleimide-dPEG
- Mal-PEG-Mal
- BM(PEO)2
- BM-PEO3
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