SimpleChIP Enzymatic Chromatin IP Kit (Magnetic Beads)
Ó¢ÎÄÃû³Æ£º SimpleChIP Enzymatic Chromatin IP Kit (Magnetic Beads)
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Chromatin Regulation / Acetylation 

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Sulfhydryl-to-sulfhydryl crosslinkers with polyethylene glycol (PEG) spacer arms.

BM(PEG)2 and BM(PEG)3 are bismaleimide-activated PEG compounds for crosslinking between sulfhydryl (¨CSH) groups in proteins and other thiol molecules. The maleimide groups at either end of the PEG2 or PEG3 spacer react specifically and efficiently with reduced sulfhydryls at pH 6.5-7.5 to form stable thioether bonds.

BM(PEG), bis-maleimide crosslinkers with polyethylene glycol (PEG) spacer arms

Highlights:

  • Irreversibly crosslink reduced cysteine by flexible PEG/PEO spacer arms
  • Polyethylene glycol spacer arms help maintain conjugate solubility
  • Pure compound with defined structure and molecular weight, ensuring reproducible protein-modification effects
  • PEG spacer provides unique advantages, including increased stability, reduced tendency toward aggregation and reduced immunogenicity
  • Ideal for small molecule or peptide conjugations
  • Maleimides react with ¨CSH groups at pH 6.5-7.5, forming stable thioether linkages
  • Reactive groups: maleimide (homobifunctional)
  • Reactive toward: sulfhydryl groups

Alternative Names for BM(PEG)n:

  • Bismaleimide-dPEG
  • Mal-PEG-Mal
  • BM(PEO)2
  • BM-PEO3

Related Products

Non-PEG Bis-maleimide Crosslinkers
Amine-reactive PEG Crosslinkers
Other kinds of PEGylation Reagents

Product #

Description

Pkg. Size

22336

BM(PEG)2
(1,8-Bis-maleimido-diethyleneglycol)

50 mg

22337

BM(PEG)3
(1,11-Bis-maleimido-triethyleneglycol)

50 mg