MAP2K1 Gene Description Mitogen-activated protein kinase kinase 1 Alternative Names MEK1; MKK1; MAPKK1; PRKMK1 Molecular Weight 48 kDa Summary The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.1

Western blot data of an siRNA transfection experiment. A549 cells were lysed 72 hours after transfection. Cells were transfected with Transfection Reagent alone (Lane 1), 100nM ON-TARGETplus siCONTROL Non-Targeting Pool (Lane 2), or 100nM ON-TARGETplus MAP2K1 siRNA (Lane 3). Western blot data for Cycolphilin B is included as a control for equal protein loading.

Special Notes
*siRNA targets Human gene product.

Product #	Description	Pkg. Size
82377	Anti-MAP2K1 Protein Antibody	120 µl