MAPK8 Gene Description mitogen-activated protein kinase 8 Alternative Names JNK, JNK1, PRKM8, SAPK1, JNK1A2, JNK21B1/2 Molecular Weight 46 kDa Summary The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrome c-mediated cell death pathway. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.1

Western blot data of siRNA transfection experiment. A549 cells were lysed 72 hours after transfection. Cells were transfected with Transfection Reagent alone (Lane 1), 100nM ON-TARGETplus siCONTROL Non-Targeting Pool (Lane 2), or 100nM ON-TARGETplus MAPK8 siRNA (Lane 3). Western blot data for Cyclophilin B is included as a control for equal protein loading.

Special Notes
*siRNA targets Human gene product.

Product #	Description	Pkg. Size
82381	Anti-MAPK8 Protein Antibody	525 µl