E-64蛋白酶抑制剂(N-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺) 英文名称: E-64蛋白酶抑制剂 | |||||||||||||||
型号:null 产品货号: E3132 | |||||||||||||||
价格:请致电:010-57128832,18610462672 | |||||||||||||||
品牌: 美国 | |||||||||||||||
E-64蛋白酶抑制剂 基本信息 英文名:E-64 别名:trans-Epoxysuccinyl-L-leucylamido(4-guanidino)butane;N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylamide 产品名称:N-(反式-环氧丁二酰基)-L-亮氨酸-4-胍基丁基酰胺 分子式:C15H27N5O5 分子量:357.41 CAS 登录号:66701-25-5 产品描述: Preparation Note: E-64 is soluble in water. A 20 mg/ml solution can be prepared in water (heat may be needed). A suggested stock solution is a Biochem/physiol Actions: E-64 is an irreversible, potent, and highly selective cysteine protease inhibitor. E-64 does not react with the functional thiol group of non-protease enzymes, such as L-lactate dehydrogenase or creatine kinase. E-64 will not inhibit serine proteases (except trypsin) like other cysteine protease inhibitors, leupeptin and antipain. The trans-epoxysuccinyl group (active moiety) of E-64 irreversibly binds to an active thiol group in many cysteine proteases, such as papain, actinidase, and cathepsins B, H, and L to form a thioether linkage. E-64 is a very useful cysteine protease inhibitor for use in in vivo studies because it has a specific inhibition, it is permeable in cells and tissues and has low toxicity. Solubility:H2O: soluble1 mM (Stock Solutions stable for months at –20° C.) storage temp:2-8° 订购信息:
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