英文名称： COL2A1 Pre-design Chimera RNAi
- Specification
- Product Description:
- Homo sapiens collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) (COL2A1), transcript variant 2, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_033150
- Note:
- Position of the Chimera RNAi.
-
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1280
- Gene Name:
- COL2A1
- Gene Alias:
- ANFH,AOM,COL11A3,MGC131516,SEDC
- Gene Description:
- collagen, type II, alpha 1
- Omim ID:
- 108300, 120140, 132450, 151210, 156550, 165720, 183900, 184250, 184252, 200610, 215150, 271700, 608805
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq
- Other Designations:
- OTTHUMP00000195063,cartilage collagen,chondrocalcin,collagen II, alpha-1 polypeptide
- Gene Pathway
- Related Disease
- Asthma
- Asthma
- Cardiovascular Diseases
- Cleft Lip
- Cleft Palate
- Cumulative Trauma Disorders
- Diabetes Mellitus, Type 2
- Edema
- Gaucher Disease
- Gaucher disease
- Genetic Predisposition to Disease
- Hip Dislocation, Congenital
- Intervertebral Disk Displacement
- Legg-Perthes Disease
- Myopia
- Occupational Diseases
- Osteoarthritis
- Osteoarthritis, Hip
- Osteoarthritis, Knee