usaBrand,null 产品货号： 12353SItem#, SignalSilence UCHL1 siRNA I<br>英文名称： SignalSilence UCHL1 siRNA I

SignalSilence UCHL1 siRNA I
英文名称： SignalSilence UCHL1 siRNA I

型号:null 产品货号： 12353S

价格:请致电：010-57128832,18610462672

品牌: usa

Protein Stability

ntent">Homo sapiens ribonuclease III, nuclear (RNASEN), mRNA.

Reactivity:
Human

Storage Instruction:
Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.

Supplied Product:
DEPC water

Target Refseq:
NM_013235

Note:
Position of the Chimera RNAi.

Publication Reference

1.
dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.

2.
Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.

3.
Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.

4.
siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.

Applications

RNAi Knockdown

Application Image

RNAi Knockdown

Gene Information

Entrez GeneID:
29102

Gene Name:
RNASEN

Gene Alias:
DROSHA,ETOHI2,HSA242976,RANSE3L,RN3,RNASE3L

Gene Description:
ribonuclease type III, nuclear

Omim ID:
608828

Gene Ontology:
Hyperlink

Gene Summary:
Members of the ribonuclease III superfamily of double-stranded (ds) RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells (Fortin et al., 2002 [PubMed 12191433]). The RNase III Drosha is the core nuclease that executes the initiation step of microRNA (miRNA) processing in the nucleus (Lee et al., 2003 [PubMed 14508493]).[supplied by OMIM

Other Designations:
drosha, double-stranded RNA-specific endoribonuclease,drosha, ribonuclease type III,nuclear RNase III Drosha,putative protein p241 which interacts with transcription factor Sp1,putative ribonuclease III,ribonuclease III, nuclear

Related Disease

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