英文名称： CCR6 Pre-design Chimera RNAi
- Specification
- Product Description:
- Homo sapiens chemokine (C-C motif) receptor 6 (CCR6), transcript variant 1, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_004367
- Target Region:
- Coding sequence
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1235
- Gene Name:
- CCR6
- Gene Alias:
- BN-1,CD196,CKR-L3,CKR6,CKRL3,CMKBR6,DCR2,DRY-6,GPR-CY4,GPR29,GPRCY4,STRL22
- Gene Description:
- chemokine (C-C motif) receptor 6
- Omim ID:
- 601835
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq
- Other Designations:
- G protein-coupled receptor 29,OTTHUMP00000017618,OTTHUMP00000017619,chemokine (C-C) receptor 6,chemokine receptor-like 3,seven-transmembrane receptor, lymphocyte, 22
- Related Disease
- Acquired Immunodeficiency Syndrome
- Arthritis, Rheumatoid
- Birth Weight
- Cleft Lip
- Cleft Palate
- Crohn Disease
- Crohn's disease
- Genetic Predisposition to Disease
- Glioblastoma
- Glioma
- HIV Infections
- Inflammatory Bowel Diseases
- Leukemia
- Leukemia, Myeloid, Acute
- Meningeal Neoplasms
- Meningioma
- Tobacco Use Disorder
- Vitiligo