英文名称： DNMT2 Pre-design Chimera RNAi
- Specification
- Product Description:
- Homo sapiens DNA (cytosine-5-)-methyltransferase 2 (DNMT2), transcript variant d, mRNA.
- Reactivity:
- Human
- Storage Instruction:
- Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
- Supplied Product:
- DEPC water
- Target Refseq:
- NM_176084
- Target Region:
- 3' Untranslated Region (3'UTR)
- Note:
- Position of the Chimera RNAi.
The related RNAi products listed below were designed from different accesion number but sharing the same RNAi sequence. -
- Publication Reference
- 1.
- dsCheck: highly sensitive off-target search software for double-stranded RNA-mediated RNA interference.
Naito Y, Yamada T, Matsumiya T, Ui-Tei K, Saigo K, Morishita S.Nucleic Acids Res. 2005 Jul 1;33(Web Server issue):W589-91.
- 2.
- Functional dissection of siRNA sequence by systematic DNA substitution: modified siRNA with a DNA seed arm is a powerful tool for mammalian gene silencing with significantly reduced off-target effect.
Ui-Tei K, Naito Y, Zenno S, Nishi K, Yamato K, Takahashi F, Juni A, Saigo K.Nucleic Acids Res. 2008 Apr;36(7):2136-51. Epub 2008 Feb 11.
- 3.
- Guidelines for the selection of highly effective siRNA sequences for mammalian and chick RNA interference.
Ui-Tei K, Naito Y, Takahashi F, Haraguchi T, Ohki-Hamazaki H, Juni A, Ueda R, Saigo K.Nucleic Acids Res. 2004 Feb 9;32(3):936-48. Print 2004.
- 4.
- siDirect: highly effective, target-specific siRNA design software for mammalian RNA interference.
Naito Y, Yamada T, Ui-Tei K, Morishita S, Saigo K.Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W124-9.
- Application Image
- RNAi Knockdown
- Entrez GeneID:
- 1787
- Gene Name:
- TRDMT1
- Gene Alias:
- DNMT2,M.HsaIIP,PuMet,RNMT1
- Gene Description:
- tRNA aspartic acid methyltransferase 1
- Omim ID:
- 602478
- Gene Ontology:
- Hyperlink
- Gene Summary:
- This gene encodes a protein responsible for the methylation of aspartic acid transfer RNA. While similar in sequence and structure to DNA cytosine methyltransferases, this gene is distinct and highly conserved in its function among taxa. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq
- Other Designations:
- DNA (cytosine-5-)-methyltransferase 2,DNA MTase homolog HsaIIP,DNA methyltransferase homolog HsaIIP,DNA methyltransferase-2,OTTHUMP00000019228,OTTHUMP00000045198,tRNA aspartic acid methyltransferase 1 variant 1,tRNA aspartic acid methyltransferase 1 varia
- Gene Pathway
- Related Disease
- Alzheimer disease
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Small Cell
- Cerebral Hemorrhage
- Genetic Predisposition to Disease
- Hypertension
- Intracranial Hemorrhages
- Lung carcinoma, small cell
- Lung Neoplasms
- Neoplasms, Glandular and Epithelial
- Ovarian cancer
- Ovarian Neoplasms
- Spinal Dysraphism
- Stroke
- Subarachnoid Hemorrhage