PSEN1 Pre-design Chimera RNAi
英文名称: PSEN1 Pre-design Chimera RNAi
型号:null    产品货号: H00005663-R01
价格:请致电:010-57128832,18610462672
品牌: 台湾

  • Specification
  • Product Description:
  • Homo sapiens presenilin 1 (Alzheimer disease 3) (PSEN1), transcript variant I-467, mRNA.
  • Reactivity:
  • Human
  • Storage Instruction:
  • Store at -20°C, do not exceed 4 - 5 freeze-thaw cycles to ensure product integrity.
  • Supplied Product:
  • DEPC water
  • Target Refseq:
  • NM_000021
  • Note:
  • Position of the Chimera RNAi.

  • Publication Reference
  • Applications
  • RNAi Knockdown
  • Application Image
  • RNAi Knockdown
  • Gene Information
  • Entrez GeneID:
  • 5663
  • Gene Name:
  • PSEN1
  • Gene Alias:
  • AD3,FAD,PS1,S182
  • Gene Description:
  • presenilin 1
  • Gene Summary:
  • Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq
  • Other Designations:
  • -

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