Recombinant Human CLDN11, Fc-tagged
英文名称： Recombinant Human CLDN11, Fc-tagged
型号:null    产品货号： CLDN11-8557H
价格:请致电：010-57128832,18610462672
品牌: usa

 http://www.creativebiomart.net/description_382698_12.htm

Claudin-11, also known as CLDN11, belongs to the group of claudins. Claudins are integral membrane proteins and components of tight junction strands. As a physical barrier, tight junction strands can prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. Claudin-11 plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. A dysfunction of CLDN11 gene may cause human blood-testis barrier disruption. CLDN11 plays an important role in regulating proliferation and migration of oligodendrocytes.

鸦钚灾饕硐衷诮侵市纬上赴皇浅上宋赴湍谄は赴�研究这个基因的大鼠和小鼠的同源基因表明，其在上皮的生长、分化、再生和迁移中起作重要的生理功能，同时在伤口的上皮愈合，毛囊发育及早期肺器官生成方面发挥作用。

货号： RP1020 

别名：HBGF-7, FGF7, FGF-7, KGF.

说明：人角质细胞生长因子KGF由原核表达系统（E.coli）重组表达制备，该蛋白由164个氨基酸残基组成的非糖基化的一条多肽链，分子量约 19kDa，带his标签。

来源：大肠杆菌。

纯度：SDS-PAGE检测纯度大于95％。

内毒素水平：LAL方法检测，内毒素水平 小于0.1 ng/μg (1EU/μg)。

生物活性：使用不同剂量的KGF刺激表达KGF受体的BaF3细胞，通过检测胸腺嘧***的摄入量，测得ED50（半数有效量）为10ng/ml， 对应的比活性为1.0×105 IU/mg。

氨基酸序列： 

MCNDMTPEQM ATNVNCSSPE RHTRSYDYME GGDIRVRRLF CRTQWYLRID KRGKVKGTQE 
MKNNYNIMEI RTVAVGIVAI KGVESEFYLA MNKEGKLYAK KECNEDCNFK ELILENHYNT 
YASAKWTHNG GEMFVALNQK GIPVRGKKTK KEQKTAHFLP MAIT

复溶：

本产品从10 mM PBS（pH值7.4）经冷冻干燥制备，我们建议将冻干的人角质细胞生长因子KGF（10 mW-cm H2O）溶解。浓度不低于100μg/ml，以待进一步稀释至工作浓度。

贮存：

无菌冻干粉剂：可在室温下存放3周，对其活性无明显影响；长期保存请存放于-20℃以下，可稳定保存至少一年。

复溶后的细胞因子（请按推荐的复溶条件进行，如需进一步稀释，请查考相关文献）：复溶后，人角质细胞生长因子KGF应贮存在4℃下，长期储存在-20℃，建议加保护剂（0.1％HSA或BSA）。可稳定保存至少三个月。应避免反复冻融。

nt-size: 12px; width: 688px; border: 1px solid rgb(240, 240, 240); height: auto;">Storage: Avoid repeated freeze/thaw cycles. Store at 2-8oC for one month. Aliquot and store at -80oC for 12 months.
Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by  聚集蛋白聚糖(AGC)重组蛋白accelerated thermal degradation test, that is, incubate the protein at 37oC for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
About the MARKER (complimentary)

 

Effective Size Range: 10kDa to 70kDa.
Protein bands: 10kDa, 14kDa, 18kDa, 22kDa, 26kDa, 33kDa, 44kDa and 70kDa.
Double intensity bands: The 26kDa, 18kDa, 10kDa bands are at double intensity to make location and size approximation of proteins of interest quick and easy.

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