http://www.creativebiomart.net/description_382670_12.htm

HB-GAM belongs to the pleiotrophin family. It is structurally related to midkine and retinoic acid induced heparin-binding protein. HB-GAM has a high affinity for heparin. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone.While in the adult central nervous system, HB-GAM is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damaged in the entorhinal cortex or in the substantia nigra pars compacta. As a secreted growth factor, HB-GAM induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells. It also binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation.