PKM2抗原蛋白
英文名称： PKM2 Kinase
型号:null    抗体货号： AA002
价格:请致电：010-57128832,18610462672
品牌: 国源    产品商标: 国源

PKM2 抗原蛋白
M2型丙***酸激酶（PKM2）一种在癌细胞糖代谢过程中发挥关键
性作用的酶，可通过一种非代谢机制促进细胞增殖和肿瘤形成。
PKM2还具有一个意想不到的关键功能——直接调控细胞的增殖。从
根本上讲，PKM2直接参与调控了细胞生长相关的基因转录。在人类
癌细胞中证实EGFR信号活化可诱导PKM2易位进入细胞核，在细胞
核中PKM2的K433与β-catenin的c-Src***酸化Y333位点结合，随后两结
合蛋白招募至下游基因周期蛋白D1（CCND1）启动子区域，调控cyclin
D1表达，加速细胞增殖和肿瘤生成。
本品采用DNA 重组技术生产，HIS6 亲和层析纯化
产品包装：50 ug/管
纯度：>90% (PAGE 鉴定)
保存于-20°C
本产品仅供科研使用。

of genes such as MYC and
CCND1 4. c-Myc expression results in the upregulation of
GLUT1, lactate dehydrogenase A (LDHA), and, in a positive
feedback loop, PTB-dependent PKM2, which subsequently
enhances the Warburg effect 2. Cyclin D1 expression, in turn,
promotes G1-S phase transition 3, 4.
Specificity: The antibody detects endogenous levels of total PKM2 protein.
Formulation: 1.0 mg/mL in phosphate buffer without Mg2+/Ca2+, pH7.4, 150mM NaCl and 50% glycerol
Dilution: 1:500 for Western Blotting
Synonyms: PKM PK3 OIP3 PK2
Accession: Swiss-Port #: P14618-1 NCBI Gene #: 5315 NCBI Protein #: NP_872270.1
References
1 Yang W, Xia Y, Cao Y et al. EGFR-induced and PKCepsilon monoubiquitylation-dependent NF-kappaB
activation upregulates PKM2 expression and promotes tumorigenesis. Molecular cell 2012; 48:771-784.
2 Yang W, Zheng Y, Xia Y et al. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2
promotes the Warburg effect. Nature cell biology 2012; 14:1295-1304.
3 Yang W, Xia Y, Ji H et al. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation.
Nature 2011; 480:118-122.
4 Yang W, Xia Y, Hawke D et al. PKM2 phosphorylates histone H3 and promotes gene transcription and
tumorigenesis. Cell 2012; 150:685-696.
PKM2 Antibody
Catalog: #AA001 100 ul
Orders: gmxhwh@hotmail.com
Application Species Reactivity Source Storage
WB, IP Human Mouse Monoclonal Ab -20 C