gene operationBrand,null 产品货号： IPA1016-0005MGItem#, GSK690693<br>英文名称： GSK690693

GSK690693，≥98%

【英文同义名】：GSK-690693, GSK690693, gsk 690693, gsk-690693, gsk690693.

【中文同义名】：

订购信息：（原装进口，常备现货）

品牌	产品名称	产品货号	规格	目录价（元）
Gene Operation	GSK690693	IPA1016-0005MG	5 mg	¥739.00
		IPA1016-0010MG	10 mg	¥1,339.00
		IPA1016-0050MG	50mg	¥6,119.00

产品描述

GSK690693是一种强效的、ATP竞争性的AKT抑制剂，作用于AKT1,2,3的IC₅₀分别为2，13和 9 nmol/L^[1]。体内体外研究证明，GSK690693显著增加了肿瘤细胞对辐照的敏感性。另外，GSK690693也抑制了卵巢癌、乳腺癌和小鼠中前列腺肿瘤的生长，并且对急性淋巴细胞白血病细胞系有明显的拮抗作用^[2]。目前，GSK690693正处于淋巴瘤和癌症一期阶段的临床研究。

靶点

Targets	Akt1	Akt2	Akt3
IC₅₀	2 nmol/L	13nmol/L	9nmol/L^[1]

化学特性

Cas No.: 937174-76-0	M. Wt.: 425.48
Formula: C₂₁H₂₇N₇O₃	Purity: ≥98%
Synonym: GSK-690693, GSK690693, gsk 690693, gsk-690693, gsk690693.
Chemical Name: 4-(2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-((S)-piperidin-3-ylmethoxy)-1H-imidazo[4,5-c]pyridin-4-yl)-2-methylbut-3-yn-2-ol
Appearance: white to beige
Solubility: Soluble in DMSO (5mg/ml)
Storage：Store powder at -20 ºC for the stability of three years.

结构式

Reference

[1] Rhodes N,et al. Characterization of an Akt kinase inhibitor with potent pharmacodynamic and antitumor activity. Cancer Res. 68(7):2366-74(2008).

[2] Chen W,et al. Effect of AKT inhibition on epithelial-mesenchymal transition and ZEB1-potentiated radiotherapy in nasopharyngeal carcinoma. Oncol Lett. 6(5):1234-1240(2013).

[3] Hers I, et al. Akt signalling in health and disease. Cell Signal. 23(10):1515-27(2011).

Synonym: GSK-690693, GSK690693, gsk 690693, gsk-690693, gsk690693.

Appearance: white to beige